INT128795

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HIF1A) signal transduction (HIF1A) nucleolus (HIF1A)
nucleus (HIF1A) transcription factor binding (HIF1A) cytoplasm (HIF1A)
HIF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 4 99.84 Very High Very High Very High
agonist 2 99.44 Very High Very High Very High
aspirin 4 95.84 Very High Very High Very High
Kappa opioid receptor 1 89.36 High High
Opioid 2 78.60 Quite High
Analgesic 1 74.64 Quite High
cINOD 1 28.88 Quite Low
Angina 4 22.52 Low Low
ischemia 9 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 11 99.84 Very High Very High Very High
Injury 5 94.00 High High
Herpes Simplex Virus 1 67.52 Quite High
Peripheral Arterial Disease 8 64.52 Quite High
Coronary Artery Disease 9 57.00 Quite High
Disease 4 53.68 Quite High
Wound Healing 2 49.04 Quite Low
Cv General 3 Under Development 4 22.52 Low Low
Cv Unclassified Under Development 8 5.00 Very Low Very Low Very Low
Myocardial Infarction 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the selective agonists of opioid receptors tested affected HIF-1 activation by hypoxia.
Regulation (affected) of Positive_regulation (activation) of HIF-1 associated with hypoxia, agonist and opioid receptor
1) Confidence 0.61 Published 2005 Journal J Anesth Section Abstract Doc Link 16032459 Disease Relevance 0.45 Pain Relevance 0.54
The aim of the present study was to analyze the role of iNOS-derived NO in HIF-1alpha stabilization and TFF gene expression in damaged gastric mucosa.
Spec (analyze) Regulation (role) of Positive_regulation (stabilization) of HIF-1alpha
2) Confidence 0.26 Published 2010 Journal FASEB J. Section Abstract Doc Link 19741170 Disease Relevance 0.18 Pain Relevance 0.12
Intracellular oxygen concentration regulates HIF-1 activity by influencing both stability and transcriptional activity of the HIF-1?
Regulation (influencing) of Positive_regulation (stability) of HIF-1
3) Confidence 0.03 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.32 Pain Relevance 0

General Comments

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