INT128842

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Context Info
Confidence 0.73
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 1
ovary 1
PDZK1IP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 2 98.46 Very High Very High Very High
Desipramine 13 96.78 Very High Very High Very High
antidepressant 7 95.90 Very High Very High Very High
noradrenaline 1 85.16 High High
Dopamine 1 84.44 Quite High
imagery 1 35.84 Quite Low
anesthesia 1 25.00 Low Low
monoamine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 3 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 1 92.64 High High
Reperfusion Injury 1 90.00 High High
Bronchiolitis Obliterans 1 57.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After starting administration of adrenaline, under the diagnosis of right heart failure, both sABP and sPAP were normalized and circulatory status got stable until the end of operation.
Localization (normalized) of sPAP in heart associated with cv general 4 under development
1) Confidence 0.73 Published 2010 Journal Masui Section Abstract Doc Link 20169963 Disease Relevance 0.50 Pain Relevance 0.08
The effects of the antidepressant drugs clomipramine (CLOM), desipramine (DMI), tianeptine (TIAN) and of norfluoxetine (NORF, the active metabolite of fluoxetine), were investigated in CHO cells expressing human beta2 adrenoceptors and a secreted placental alkaline phosphatase (SPAP) reporter gene to determine their actions on cyclic AMP-driven gene transcription.
Localization (secreted) of SPAP associated with desipramine, antidepressant and fluoxetine
2) Confidence 0.36 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17382299 Disease Relevance 0 Pain Relevance 0.36
The model comprised CHObeta2 SPAP cells; Chinese hamster ovary cells expressing human beta2 adrenoceptors and a secreted placental alkaline phosphatase (SPAP) reporter gene with multiple cAMP response elements (CREs) in its promoter region.
Localization (secreted) of SPAP in ovary
3) Confidence 0.25 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16036225 Disease Relevance 0 Pain Relevance 0.26

General Comments

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