INT12885

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Context Info
Confidence 0.53
First Reported 1989
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 2
hippocampus 2
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 3 100.00 Very High Very High Very High
depression 1 100.00 Very High Very High Very High
Serotonin 1 99.68 Very High Very High Very High
Hippocampus 3 98.36 Very High Very High Very High
fortral 6 93.00 High High
adenocard 1 88.32 High High
opiate 1 86.88 High High
Neurotransmitter 2 83.12 Quite High
Disease Link Frequency Relevance Heat
Depression 1 100.00 Very High Very High Very High
Urological Neuroanatomy 3 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of preliminary experiments, 30 nM spiperone was included in the assay medium in the frontal cortex (to block binding to D2 dopamine and S2 serotonin sites), but not in the hippocampus or cerebellum; the specific binding was defined by inhibition by 30 or 100 microM (+)3-(3-hydroxy)-N-(1-propyl)piperidine.
Negative_regulation (block) of D2 dopamine Binding (binding) of in hippocampus associated with dopamine, urological neuroanatomy, hippocampus and serotonin
1) Confidence 0.53 Published 1991 Journal Yakubutsu Seishin Kodo Section Abstract Doc Link 1656649 Disease Relevance 0.16 Pain Relevance 0.31
A marginal depression in dopamine D-2 binding in the striatum was noted.
Negative_regulation (depression) of dopamine D-2 Binding (binding) of in striatum associated with dopamine and depression
2) Confidence 0.32 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2542043 Disease Relevance 0.10 Pain Relevance 0.41

General Comments

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