INT128864

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 5.35
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KIR2DS2)
Anatomy Link Frequency
T cells 2
articular 1
KIR2DS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 8 98.74 Very High Very High Very High
Inflammation 54 98.08 Very High Very High Very High
agonist 4 97.76 Very High Very High Very High
rheumatoid arthritis 135 97.54 Very High Very High Very High
antagonist 4 94.48 High High
Arthritis 9 93.92 High High
cytokine 12 86.44 High High
opioid receptor 1 81.44 Quite High
spinal inflammation 6 80.24 Quite High
Opioid 2 79.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 57 98.08 Very High Very High Very High
Rheumatoid Arthritis 135 97.54 Very High Very High Very High
Disease 60 97.20 Very High Very High Very High
Rheumatoid Vasculitis 6 95.80 Very High Very High Very High
Seronegative Spondarthritis 6 93.92 High High
Synovitis 3 89.44 High High
Infection 8 84.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 84.04 Quite High
Neurological Disease 2 82.56 Quite High
Low Back Pain 6 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, expression of KIR2DS2 had functional implications in that it sensitized the T cells to respond to subthreshold TCR stimulation.
Gene_expression (expression) of KIR2DS2 in T cells
1) Confidence 0.34 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 1.29 Pain Relevance 0.44
In patients with RA, in particular those who have extra-articular manifestations, oligoclonal T-cell populations were found to preferentially express the stimulatory KIR2DS2 gene, often in the absence of inhibitory KIRs or inhibitory receptors of the c-type lectin family, CD94/NKG2A [75].
Gene_expression (express) of KIR2DS2 in articular associated with rheumatoid arthritis
2) Confidence 0.30 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 1.18 Pain Relevance 0.44
The KIR2DS2 gene, present in only 40% of a healthy Caucasian population, was found in association studies to be a risk factor for rheumatoid vasculitis [73].
Gene_expression (present) of KIR2DS2 associated with rheumatoid vasculitis
3) Confidence 0.27 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193735 Disease Relevance 1.34 Pain Relevance 0.46
T cells that express both DAP12 and activating KIR (Killer-cell Ig-like Receptor) have been described in patients suffering from chronic inflammatory diseases [6], [7].
Gene_expression (express) of Killer-cell Ig-like Receptor in T cells associated with inflammation and disease
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.29 Pain Relevance 0.14
To further analyze its specificity, a flow cytometry analysis of DAP12 expression was performed on RBL cells expressing DAP12 (RBL-CD158j/DAP12) or not (RBL-CD158j).
Neg (not) Gene_expression (expressing) of CD158j
5) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.46 Pain Relevance 0.06
To further analyze its specificity, a flow cytometry analysis of DAP12 expression was performed on RBL cells expressing DAP12 (RBL-CD158j/DAP12) or not (RBL-CD158j).
Neg (not) Gene_expression (expressing) of CD158j
6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.45 Pain Relevance 0.06
PHA stimulation increased activation of the MOR promoter as well as levels of MOR mRNA, total receptor protein in cell lysates, and surface and cytoplasmic receptor expression.
Gene_expression (expression) of cytoplasmic receptor associated with mu opioid receptor
7) Confidence 0.04 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036794 Disease Relevance 0.33 Pain Relevance 0.85

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