INT128868

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.26
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mcrs1)
Anatomy Link Frequency
optic nerve 1
Mcrs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 64 100.00 Very High Very High Very High
gABA 8 99.70 Very High Very High Very High
tetrodotoxin 8 99.52 Very High Very High Very High
headache 4 96.00 Very High Very High Very High
Neurotransmitter 2 80.44 Quite High
sodium channel 2 77.92 Quite High
imagery 4 64.60 Quite High
Somatostatin 6 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 70 100.00 Very High Very High Very High
Infection 2 99.32 Very High Very High Very High
Loss Of Sense Of Smell 4 98.92 Very High Very High Very High
Headache Disorders 2 96.48 Very High Very High Very High
Cold Sores 8 90.32 High High
Herpes Simplex Virus 4 75.00 Quite High
Weight Gain 2 47.20 Quite Low
Targeted Disruption 2 20.92 Low Low
Pseudotumor Cerebri 6 13.28 Low Low
Natriuresis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 2 h post infection, both TTX and GABA significantly up-regulated the levels of transcription for the viral immediate early (IE) genes ICP0, ICP4, and ICP27, as revealed by real time PCR.
Positive_regulation (up-regulated) of ICP27 associated with tetrodotoxin, gaba and infection
1) Confidence 0.03 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036805 Disease Relevance 0.56 Pain Relevance 0.61
At 2 h post infection, both TTX and GABA significantly up-regulated the levels of transcription for the viral immediate early (IE) genes ICP0, ICP4, and ICP27, as revealed by real time PCR.
Positive_regulation (up-regulated) of ICP4 associated with tetrodotoxin, gaba and infection
2) Confidence 0.03 Published 2005 Journal J. Neurovirol. Section Abstract Doc Link 16036805 Disease Relevance 0.55 Pain Relevance 0.61
They hypothesized that chronically elevated ICP is neurologically damaging, even in patients without significant visual dysfunction or intractable headache.
Positive_regulation (elevated) of ICP associated with headache disorders, headache and cva
3) Confidence 0.01 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2531074 Disease Relevance 1.10 Pain Relevance 0.59
He found that patients with elevated ICP have a decreased sense of smell and concluded that other nerves such as the olfactory nerve may be functionally compromised in the setting of IH by a mechanism similar to that of optic nerve compression.
Positive_regulation (elevated) of ICP in optic nerve associated with cva and loss of sense of smell
4) Confidence 0.01 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2531074 Disease Relevance 1.06 Pain Relevance 0.50

General Comments

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