INT12887

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Context Info
Confidence 0.60
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 20
Disease Relevance 15.41
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
plasma 4
lung 2
spinal 1
marginal zone 1
capillary 1
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 99.90 Very High Very High Very High
Enkephalin 6 99.46 Very High Very High Very High
Inflammation 86 99.20 Very High Very High Very High
Morphine 2 98.98 Very High Very High Very High
dexamethasone 8 98.78 Very High Very High Very High
Arthritis 12 98.66 Very High Very High Very High
substance P 18 90.96 High High
corticosteroid 3 90.00 High High
MU agonist 1 87.36 High High
cva 13 85.12 High High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 57 99.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 1056 99.88 Very High Very High Very High
INFLAMMATION 102 99.72 Very High Very High Very High
Cancer 15 99.70 Very High Very High Very High
Disease 150 99.48 Very High Very High Very High
Myocardial Infarction 1 99.28 Very High Very High Very High
Injury 168 99.24 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 12 98.92 Very High Very High Very High
Arthritis 12 98.66 Very High Very High Very High
Hyperplasia 1 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased activity of NEP in BALF might, therefore, reflect alveolar injury with secondary shedding from the cell surface.
Positive_regulation (increased) of NEP associated with injury
1) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.03 Pain Relevance 0.10
A recent study has also found an elevated NEP activity in the cerebro-spinal fluid of patients suffering from Alzheimer's disease, attributed to synaptic disruption [37].
Positive_regulation (elevated) of NEP in spinal associated with disease
2) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.99 Pain Relevance 0.13
An alternate explanation for the increase in NEP activity in BALF may be the extravascular leakage of its soluble isoform in response to the alveolar-capillary barrier injury.
Positive_regulation (increase) of NEP in capillary associated with injury
3) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.01 Pain Relevance 0.16
The systemic downregulation and intra-alveolar upregulation of NEP activity were also more marked in the LPS group; therefore, the regulation of its activity may be modulated in response to the severity of lung injury.
Positive_regulation (upregulation) of NEP in lung associated with lung injury
4) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.64 Pain Relevance 0.04
We did not exclude intra-alveolar inflammatory cells, including PMN, as the source of increased NEP activity in BALF.
Positive_regulation (increased) of NEP associated with inflammation
5) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.86 Pain Relevance 0.16
Likewise, studies of diabetic retinopathy and idiopathic arthritis found that the tissue injury due to the inflammatory response can increase the extracellular NEP activity in the interstitial space [23,36].
Positive_regulation (increase) of NEP associated with inflammatory response, injury, diabetic retinopathy and arthritis
6) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.06 Pain Relevance 0.13
Assay of endogenous enkephalin degrading activity showed increased enkephalinase activity in striatal issue of C57BL/6J compared with DBA/2 tissue.
Positive_regulation (increased) of enkephalinase associated with enkephalin
7) Confidence 0.60 Published 1991 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 1656811 Disease Relevance 0.24 Pain Relevance 0.97
-secretase cleavage, and FAD-associated PS1 mutations increase neprilysin levels in brains of patients with mutant PS1 alleles [87].
Positive_regulation (increase) of neprilysin in brains associated with disease
8) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.74 Pain Relevance 0.05
Furthermore, the expression and activity of neprilysin, an A?
Positive_regulation (activity) of neprilysin
9) Confidence 0.45 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.78 Pain Relevance 0.06
In addition, the NEP activity was higher in the LPS-treated mice, in which the recruitment of PMN into the air-space was increased.
Positive_regulation (higher) of NEP
10) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.94 Pain Relevance 0.16
Elevated NEP activity in the BALF of mice with acute lung injury
Positive_regulation (Elevated) of NEP in lung associated with adult respiratory distress syndrome
11) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.26 Pain Relevance 0
We also found an increase in NEP activity in the intra-alveolar space of mice with ALI, in contrast to its activity in plasma.
Positive_regulation (increase) of NEP in plasma associated with adult respiratory distress syndrome
12) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.85 Pain Relevance 0
In this experimental and clinical study of ALI/ARDS, the activity of NEP was significantly decreased in plasma and increased in the alveolar air space.



Positive_regulation (increased) of NEP in plasma associated with adult respiratory distress syndrome
13) Confidence 0.41 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3009633 Disease Relevance 0.94 Pain Relevance 0
In contrast, the activity of NEP in the BALF of LPS-treated mice was increased.
Positive_regulation (increased) of NEP
14) Confidence 0.41 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3009633 Disease Relevance 1.41 Pain Relevance 0
In this experimental and clinical study of ALI/ARDS, the activity of NEP was significantly decreased in plasma and increased in the alveolar air space.



Positive_regulation (activity) of NEP in plasma associated with adult respiratory distress syndrome
15) Confidence 0.41 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3009633 Disease Relevance 0.94 Pain Relevance 0
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Positive_regulation (include) of CD10 in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
16) Confidence 0.11 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.15 Pain Relevance 0
Immunological marker studies of the tumor cell revealed increasing of anti J-5 (CD10), anti B-4 (CD19) and OKT-IA1.
Positive_regulation (increasing) of CD10 associated with cancer
17) Confidence 0.09 Published 1989 Journal No Shinkei Geka Section Abstract Doc Link 2812271 Disease Relevance 0.73 Pain Relevance 0.12
Immunohistochemically, the histiocytic cells were positive for vimentin, CD68, and lysozyme and were negative for cytokeratin, S100 protein, estrogen and progesterone receptors, and CD10.
Positive_regulation (negative) of CD10
18) Confidence 0.07 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 15335251 Disease Relevance 0.67 Pain Relevance 0.08
Intravenous morphine reduces plasma endothelin 1 concentration through activation of neutral endopeptidase 24.11 in patients with myocardial infarction.
Positive_regulation (activation) of neutral endopeptidase 24.11 in plasma associated with myocardial infarction and morphine
19) Confidence 0.03 Published 2001 Journal Ann Emerg Med Section Title Doc Link 11326179 Disease Relevance 0.10 Pain Relevance 0.20
Because these reactivity studies were consistent with the possibility that dexamethasone may ameliorate ozone-induced, tachykinin hyperreactivity by stimulating airway neutral endopeptidase (NEP), we measured NEP activity by high-performance liquid chromatography (HPLC) of each tracheal homogenate made from other groups of animals.
Positive_regulation (stimulating) of neutral endopeptidase associated with dexamethasone
20) Confidence 0.02 Published 1993 Journal Lung Section Abstract Doc Link 7678875 Disease Relevance 0.07 Pain Relevance 0.56

General Comments

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