INT128882

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.96
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Lgals1) cytoplasm (Lgals1) signal transducer activity (Lgals1)
extracellular space (Lgals1) signal transduction (Lgals1) extracellular region (Lgals1)
Lgals1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 5 95.64 Very High Very High Very High
fibrosis 2 95.12 Very High Very High Very High
cytokine 1 88.08 High High
Chronic pancreatitis 2 70.12 Quite High
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 2 99.84 Very High Very High Very High
Fibrosis 2 95.12 Very High Very High Very High
Lower Urinary Tract Symptoms 6 81.68 Quite High
Overactive Bladder 11 79.12 Quite High
Benign Prostatic Hypertrophy 8 77.28 Quite High
Pancreatic Cancer 2 71.00 Quite High
Pancreatitis 2 70.12 Quite High
Stress 5 5.00 Very Low Very Low Very Low
Stress Incontinence 4 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, our data implicate gal-1 in PSC activation and suggest further studies to analyse the role of endogenous lectins in the development of pancreatic fibrosis in vivo.
Spec (implicate) Negative_regulation (implicate) of gal-1 associated with fibrosis and primary sclerosing cholangitis
1) Confidence 0.42 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 16038798 Disease Relevance 0.48 Pain Relevance 0.15
These effects of galectin-1 were abolished in the presence of thiodigalactosie, an inhibitor of beta-galactoside binding.
Negative_regulation (abolished) of galectin-1
2) Confidence 0.40 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16373424 Disease Relevance 0.11 Pain Relevance 0.26
Beta-galactoside-binding lectin was shown to be decreased transiently at 24 hr.
Negative_regulation (decreased) of Beta-galactoside-binding lectin
3) Confidence 0.12 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.37 Pain Relevance 0

General Comments

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