INT12890

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 7.68
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ttr) extracellular space (Ttr) extracellular region (Ttr)
Anatomy Link Frequency
Plasma 3
liver 3
duct 1
Ttr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 8 99.96 Very High Very High Very High
analgesia 3 96.72 Very High Very High Very High
epidural 3 96.52 Very High Very High Very High
Bile 2 92.04 High High
alcohol 2 89.68 High High
Neuropathic pain 2 85.88 High High
anesthesia 1 85.36 High High
diabetic neuropathy 4 81.80 Quite High
carpal tunnel syndrome 3 77.76 Quite High
Angina 1 75.12 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 5 100.00 Very High Very High Very High
Pancreatitis 18 99.96 Very High Very High Very High
Amyloidosis 13 98.58 Very High Very High Very High
Pancreatic Cancer 4 98.40 Very High Very High Very High
Sepsis 10 96.20 Very High Very High Very High
Jaundice 1 95.08 Very High Very High Very High
Disease 79 94.64 High High
Intraoperative Complications 2 94.56 High High
Diarrhoea 72 94.36 High High
Alzheimer's Dementia 7 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ATTR amyloidosis is an autosomal dominant disorder caused by the amyloidogenic form of transthyretin, a plasmaprotein that is synthesized in the liver.
Gene_expression (synthesized) of transthyretin in liver associated with amyloidosis
1) Confidence 0.63 Published 2008 Journal Med. Klin. (Munich) Section Abstract Doc Link 18344065 Disease Relevance 1.64 Pain Relevance 0.11
TTR Arg 58 is the first mutant TTR gene that has been detected by SSCP analysis.
Gene_expression (detected) of TTR gene
2) Confidence 0.57 Published 1991 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 1656975 Disease Relevance 0.23 Pain Relevance 0.08
Comparing patients with pancreatic cancer, chronic pancreatitis or biliary duct obstruction, we observed that the plasma levels of apolipoprotein A1, transthyretin, and apolipoprotein E, when examined in isolation, were each associated with pancreatic cancer.
Gene_expression (levels) of transthyretin in duct associated with pancreatic cancer, chronic pancreatitis and disorder of lipid metabolism
3) Confidence 0.33 Published 2009 Journal J. Proteome Res. Section Abstract Doc Link 19055369 Disease Relevance 1.18 Pain Relevance 0.19
In CP, transthyretin levels were decreased in 37%, transferrin in 27%, and albumin in 12% of patients.
Gene_expression (levels) of transthyretin associated with chronic pancreatitis
4) Confidence 0.21 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12553437 Disease Relevance 1.35 Pain Relevance 0.61
The levels of albumin mRNA and transthyretin mRNA (also called prealbumin) decreased to about 80% of normal and the level of transferrin mRNA did not change significantly.
Gene_expression (levels) of transthyretin mRNA
5) Confidence 0.19 Published 1987 Journal J Trauma Section Abstract Doc Link 2435922 Disease Relevance 0.23 Pain Relevance 0.09
TTR was statistically evaluated by UNIANOVA for patient characteristics: age, gender, nursing type (breastfeeding, bottle feeding, or mixed feeding), nursing status during diarrhea (nursing or no nursing), co-medication, and diarrhea severity which were graded according to the number of watery stools in the 24 hour period prior to inclusion into the study (mild = 3–4, moderate = 5–7, and severe ?
Gene_expression (evaluated) of TTR associated with diarrhoea
6) Confidence 0.19 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909495 Disease Relevance 0.37 Pain Relevance 0
Plasma levels of prealbumin, transferrin, and albumin were found below the normal range in more than 70% in both sexes.
Gene_expression (levels) of prealbumin in Plasma
7) Confidence 0.11 Published 2008 Journal Minerva Gastroenterol Dietol Section Body Doc Link 18614973 Disease Relevance 0 Pain Relevance 0
The hereditary forms are related to a mutation in the serum protein transthyretin which is produced mainly in the liver.
Gene_expression (produced) of transthyretin in liver
8) Confidence 0.09 Published 1999 Journal Ugeskr. Laeg. Section Abstract Doc Link 10489791 Disease Relevance 0.79 Pain Relevance 0
In the liver, the rate of synthesis of selected proteins (i.e., albumin, transferrin, prealbumin, retinol-binding protein, and fibronectin) is decreased, whereas acute phase protein synthesis is accelerated [94].
Gene_expression (synthesis) of prealbumin in liver
9) Confidence 0.09 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2861661 Disease Relevance 1.16 Pain Relevance 0.15
fibrils by increasing gene expression of transthyretin [87], as transthyretin has been shown to prevent A?
Gene_expression (expression) of transthyretin
10) Confidence 0.05 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.30 Pain Relevance 0
Plasma glutathione peroxidase, similar to complement component 3 and chain A of transthyretin (TTR) were under-expressed in the sera of the AS patients.
Gene_expression (expressed) of transthyretin in Plasma
11) Confidence 0.05 Published 2010 Journal Clin. Exp. Rheumatol. Section Body Doc Link 20483041 Disease Relevance 0.13 Pain Relevance 0
However, the values compare unfavorably with an average TTR of 61% in studies in outpatients receiving warfarin. [6]
Gene_expression (average) of TTR
12) Confidence 0.04 Published 2008 Journal BMC Geriatr Section Body Doc Link PMC2464578 Disease Relevance 0 Pain Relevance 0
However, the values compare unfavorably with an average TTR of 61% in studies in outpatients receiving warfarin. [6]
Gene_expression (compare) of TTR
13) Confidence 0.04 Published 2008 Journal BMC Geriatr Section Body Doc Link PMC2464578 Disease Relevance 0 Pain Relevance 0
Comparison of the results of the two cholecystectomy techniques showed that laparoscopic cholecystectomy induced a significantly less intensive acute-phase response (area under the curve) of interleukin 6 (17 +/- 17 versus 47 +/- 26 pg/ml x hr x 10(2); p < 0.003), C-reactive protein (16 +/- 12 versus 35 +/-16 mg/dl x hr x 10; p < 0.004), and prealbumin (16 +/- 2.7 versus 13.8 +/- 2.3 mg/dl x hr x 10(2); p < 0.05).
Gene_expression (less) of prealbumin
14) Confidence 0.02 Published 1996 Journal World J Surg Section Abstract Doc Link 8661626 Disease Relevance 0.30 Pain Relevance 0.07
Plasma levels of transferrin, albumin, prealbumin, IgA, IgG, and IgM were significantly lower during the first postoperative day in the epidural group.
Gene_expression (levels) of prealbumin in Plasma associated with epidural
15) Confidence 0.01 Published 1980 Journal Acta Chir Scand Suppl Section Abstract Doc Link 6941601 Disease Relevance 0 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox