INT128912

Context Info Confidence 0.26 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0.30

nucleus (SMYD1) DNA binding (SMYD1) cytoplasm (SMYD1)

Anatomy Link Frequency cavity 1 SMYD1 (Homo sapiens)

Pain Link Frequency Relevance Heat local anesthetic 2 75.24 sodium channel 1 69.56 Pain 1 67.96 anesthesia 1 54.24

Disease Link Frequency Relevance Heat Toxicity 1 83.12 Pain 1 67.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The details of BZC/beta-CD molecular interaction were analyzed by 1H 2D NMR allowing the proposition of an inclusion model for BZC into beta-CD where the aromatic ring of the anesthetic is located near the head of the beta-CD cavity.

beta-CD Binding (interaction) of in cavity

1) Confidence 0.26 Published 2005 Journal J Pharm Biomed Anal Section Abstract Doc Link 16040222 Disease Relevance 0.15 Pain Relevance 0.30

General Comments

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