INT128915

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 1.43

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signal transduction (PENK) extracellular region (PENK) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) signal transducer activity (OPRM1)
PENK (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 8 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
Catechol-O-methyltransferase 9 99.44 Very High Very High Very High
Thalamus 4 83.84 Quite High
Nucleus accumbens 1 79.64 Quite High
opioid receptor 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a mechanism how COMT might exert its action on MOP receptors, it has been suggested that at least in striatopallidal circuits COMT Val(108/158)Met impacts on enkephalin, which is capable of reciprocally regulating MOP receptor expression.
enkephalin Regulation (regulating) of Gene_expression (expression) of MOP associated with catechol-o-methyltransferase, enkephalin and opioid
1) Confidence 0.22 Published 2005 Journal Neuroimage Section Abstract Doc Link 16040257 Disease Relevance 0.07 Pain Relevance 1.43

General Comments

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