INT12892

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 136
Total Number 138
Disease Relevance 83.13
Pain Relevance 36.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
cartilage 5
fibroblasts 5
monocytes 5
extracellular matrix 4
liver 4
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1497 100.00 Very High Very High Very High
rheumatoid arthritis 1118 99.96 Very High Very High Very High
Osteoarthritis 394 99.84 Very High Very High Very High
depression 242 99.70 Very High Very High Very High
methotrexate 45 99.70 Very High Very High Very High
cytokine 847 99.20 Very High Very High Very High
dexamethasone 24 99.02 Very High Very High Very High
Inflammation 1481 98.32 Very High Very High Very High
Dismenorea 15 98.32 Very High Very High Very High
Pain 198 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1127 99.96 Very High Very High Very High
Apoptosis 435 99.96 Very High Very High Very High
Hyperlipidemia 16 99.96 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 48 99.92 Very High Very High Very High
Osteoarthritis 452 99.84 Very High Very High Very High
Depression 280 99.70 Very High Very High Very High
Injury 417 99.64 Very High Very High Very High
Colon Cancer 44 99.64 Very High Very High Very High
Disease Progression 30 99.60 Very High Very High Very High
Disease 990 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, data from animal models indicate that chemically modified tetracycline as an inhibitor of collagenase can slow disease progression in animals.
Negative_regulation (inhibitor) of collagenase associated with disease progression
1) Confidence 0.58 Published 1996 Journal J. Clin. Periodontol. Section Abstract Doc Link 8707994 Disease Relevance 1.22 Pain Relevance 0.17
Dexamethasone inhibited PGE2 synthesis, which resulted in the suppression of collagenase.
Negative_regulation (suppression) of collagenase associated with dexamethasone
2) Confidence 0.57 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.16 Pain Relevance 0.36
However, an increase in MMP-9 activity and a decrease in TIMP-1 protein levels were observed following the establishment of uterine contractions in media conditioned by amnion.
Negative_regulation (decrease) of TIMP-1 in amnion associated with dismenorea
3) Confidence 0.55 Published 2003 Journal Mol. Hum. Reprod. Section Abstract Doc Link 12771238 Disease Relevance 0.35 Pain Relevance 0.40
We found that in media conditioned by decidua, following the establishment of uterine contractions, matrix metalloproteinase-2 (MMP-2) activity is increased while the protein tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) level is decreased.
Negative_regulation (inhibitors) of TIMP-1 in decidua associated with metalloproteinase and dismenorea
4) Confidence 0.55 Published 2003 Journal Mol. Hum. Reprod. Section Abstract Doc Link 12771238 Disease Relevance 0.34 Pain Relevance 0.39
1), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and TIMP-2 in hypertrophied ligamentum flavum of patients with lumbar spinal stenosis compared to patients with lumbar disc herniation.
Negative_regulation (inhibitor) of TIMP-1 in spinal associated with metalloproteinase and spinal stenosis
5) Confidence 0.54 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 0.80 Pain Relevance 0.20
Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].
Negative_regulation (inhibitors) of metalloproteinase TIMP1 associated with metalloproteinase
6) Confidence 0.49 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.84 Pain Relevance 0.22
Furthermore, collagenase activities measured from saliva by quantitative SDS-PAGE electrophoresis were significantly reduced during the 12-week intervention (P < 0.01).
Negative_regulation (reduced) of collagenase in saliva
7) Confidence 0.45 Published 1998 Journal Rheumatol. Int. Section Abstract Doc Link 9542777 Disease Relevance 0.51 Pain Relevance 0.53
The concentrations of cartilage proteoglycan (aggrecan), stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1) and procollagen II C-propeptide in knee joint fluid and the levels of aggrecan, hyaluronan and keratan sulfate in serum were measured before and after exercise in 33 healthy athletes.
Negative_regulation (inhibitor) of TIMP-1 in knee joint associated with metalloproteinase
8) Confidence 0.43 Published 1995 Journal Osteoarthr. Cartil. Section Abstract Doc Link 7719956 Disease Relevance 0.12 Pain Relevance 0.11
Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E2: selective enhancement of collagenase gene expression in human dermal fibroblasts in culture.
Negative_regulation (inhibitor) of collagenase in fibroblasts associated with metalloproteinase
9) Confidence 0.43 Published 1994 Journal J. Cell. Biochem. Section Title Doc Link 8014195 Disease Relevance 0.14 Pain Relevance 0.24
Blood was collected and analyzed for MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1.
Negative_regulation (inhibitor) of TIMP in Blood associated with metalloproteinase
10) Confidence 0.42 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15920174 Disease Relevance 0.08 Pain Relevance 0.70
Endogenous proteins known as tissue inhibitors of metalloproteinase (TIMPs) also regulate activities of MMPs [17].
Negative_regulation (inhibitors) of TIMP associated with metalloproteinase
11) Confidence 0.42 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.65 Pain Relevance 0.50
Serum levels of MMP-2, -3, -7, -9, and tissue inhibitor of MMP (TIMP)-1 and -2 were measured in all patients.
Negative_regulation (inhibitor) of TIMP
12) Confidence 0.42 Published 2007 Journal Atherosclerosis Section Body Doc Link 16996520 Disease Relevance 0.08 Pain Relevance 0
In other fibrotic diseases affecting organs such as the liver, lung, heart, and skin, matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), play an important role.
Negative_regulation (inhibitors) of TIMP in skin associated with fibrosis, metalloproteinase and disease
13) Confidence 0.42 Published 2003 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 14504511 Disease Relevance 0.80 Pain Relevance 0.28
In the present study, we investigated whether the ratio of MMP-9 and its endogenous inhibitor, tissue inhibitor of metalloproteinase (TIMP)-1, in circulating monocytes correlates with the clinical stages of coronary artery disease.
Spec (whether) Negative_regulation (inhibitor) of TIMP in monocytes associated with coronary artery disease and metalloproteinase
14) Confidence 0.42 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20152234 Disease Relevance 1.23 Pain Relevance 0.70
In the present study, we investigated whether the ratio of MMP-9 and its endogenous inhibitor, tissue inhibitor of metalloproteinase (TIMP)-1, in circulating monocytes correlates with the clinical stages of coronary artery disease.
Spec (whether) Negative_regulation (inhibitor) of TIMP in monocytes associated with coronary artery disease and metalloproteinase
15) Confidence 0.42 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20152234 Disease Relevance 1.23 Pain Relevance 0.70
Prolyl hydroxylase is a key enzyme in collagen synthesis, and tissue inhibitor of metalloproteinase (TIMP) is known to suppress collagenolytic enzymes.
Negative_regulation (inhibitor) of TIMP associated with metalloproteinase
16) Confidence 0.42 Published 1998 Journal Pancreas Section Abstract Doc Link 9598809 Disease Relevance 0.54 Pain Relevance 0.59
In this study, the effects of sonicated bacterial extracts (SBEs) from Prevotella intermedia, Fusobacterium nucleatum, Porphyromonas endodontalis, and Porphyromonas gingivalis on the balance between the production of matrix metalloproteinases (MMPs) and that of their inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] by HDP cells were examined.
Negative_regulation (inhibitors) of TIMP in HDP associated with metalloproteinase
17) Confidence 0.41 Published 2000 Journal J Endod Section Abstract Doc Link 11199767 Disease Relevance 0.09 Pain Relevance 0.22
1), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and TIMP-2 were measured by enzyme-linked immunosorbent assay.


Negative_regulation (inhibitor) of TIMP-1 associated with metalloproteinase
18) Confidence 0.40 Published 2007 Journal Asian Spine Journal Section Abstract Doc Link PMC2857497 Disease Relevance 0.36 Pain Relevance 0.16
These results indicate that the documented favourable clinical response may in part be due to in vivo inhibition of classic neutrophil and mesenchymal collagenase/MMP-8 activities produced by doxycycline.
Negative_regulation (inhibition) of collagenase in neutrophil
19) Confidence 0.39 Published 1998 Journal Rheumatol. Int. Section Abstract Doc Link 9542777 Disease Relevance 0.41 Pain Relevance 0.50
plus methotrexate significantly decreases serum IL-18, E-selectin, TIMP1 and MMP9 levels [53].
Negative_regulation (decreases) of TIMP1 associated with methotrexate
20) Confidence 0.38 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.53 Pain Relevance 0.22

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