INT128921

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 9.54
Pain Relevance 14.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
ACC 4
plasma 2
spinal nerve 2
spinal cord 2
microglia 2
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 154 100.00 Very High Very High Very High
Morphine 35 100.00 Very High Very High Very High
withdrawal 32 100.00 Very High Very High Very High
antagonist 16 100.00 Very High Very High Very High
Analgesic 16 100.00 Very High Very High Very High
qutenza 10 100.00 Very High Very High Very High
Glutamate 10 100.00 Very High Very High Very High
Anterior cingulate cortex 8 100.00 Very High Very High Very High
adenocard 8 100.00 Very High Very High Very High
Pain 30 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 110 99.80 Very High Very High Very High
Pain 34 99.76 Very High Very High Very High
Hyperalgesia 22 99.30 Very High Very High Very High
Neuropathic Pain 44 99.22 Very High Very High Very High
Apoptosis 3 98.92 Very High Very High Very High
Diabetes Mellitus 154 98.64 Very High Very High Very High
Temporomandibular Joint Syndrome 4 97.68 Very High Very High Very High
Inflammatory Pain 2 94.96 High High
Neuroleptic Malignant Syndrome 4 94.76 High High
Right Ventricular Hypertrophy 2 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, ACEA (10 microM) was still very effective in inhibiting capsaicin-induced pERK expression.
Negative_regulation (inhibiting) of Gene_expression (expression) of pERK associated with qutenza
1) Confidence 0.49 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16221738 Disease Relevance 0.29 Pain Relevance 2.04
When N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA-1004), a PKA inhibitor, was infused, concomitantly with morphine, it diminished the expression of ERK1/2.
Negative_regulation (diminished) of Gene_expression (expression) of ERK associated with morphine
2) Confidence 0.42 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19567779 Disease Relevance 0 Pain Relevance 1.50
In this study, we reported that intrathecal (i.t.) pretreatment with either the non-selective nitric oxide synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME), neuronal NOS (nNOS) inhibitor 7-nitro indazole (7-NI), or the inducible NOS (iNOS) inhibitor aminoguanidine (AG), could reduce morphine withdrawal-induced increase of phospho-ERK1/2 (pERK1/2) expression in the rat spinal cord.
Negative_regulation (reduce) of Gene_expression (expression) of ERK in spinal cord associated with withdrawal, spinal cord, morphine and intrathecal
3) Confidence 0.42 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16712881 Disease Relevance 0.09 Pain Relevance 1.20
Pulmonary tissue was collected to investigate pathological features of pulmonary arteries and to measure protein expression of ERK(1)/ERK(2) and MKP1.
Negative_regulation (measure) of Gene_expression (expression) of ERK
4) Confidence 0.37 Published 2010 Journal Cardiovasc Ther Section Abstract Doc Link 20074256 Disease Relevance 0.43 Pain Relevance 0.10
Pulmonary tissue was collected to investigate pathological features of pulmonary arteries and to measure protein expression of ERK(1)/ERK(2) and MKP1.
Negative_regulation (measure) of Gene_expression (expression) of ERK
5) Confidence 0.37 Published 2010 Journal Cardiovasc Ther Section Abstract Doc Link 20074256 Disease Relevance 0.43 Pain Relevance 0.10
One week after spinal nerve ligation when neuropathic pain is fully developed, capsaicin induced less pERK expression in the injured L(5)-spinal segment.
Negative_regulation (less) of Gene_expression (expression) of pERK in spinal nerve associated with qutenza, spinal nerve ligature and neuropathic pain
6) Confidence 0.36 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16221738 Disease Relevance 0.47 Pain Relevance 2.28
We found that ERK activation in the RVM is associated with mechanical hyperalgesia but that both the pain states and pERK expression are reduced by lamina I ablation.
Negative_regulation (reduced) of Gene_expression (expression) of pERK in lamina associated with pain, hyperalgesia and rostral ventromedial medulla
7) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.35 Pain Relevance 1.54
In our study, 8 days post SNI surgery, pERK expression within the RVM was limited to neurons and no glial activation was seen. p38, another MAPK involved in the maintenance of pain states, was found in microglia in the RVM 3 h after carrageenan injection into the hindpaw [27].
Negative_regulation (limited) of Gene_expression (expression) of pERK in microglia associated with pain, nervous system injury, glial activation and rostral ventromedial medulla
8) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.29 Pain Relevance 0.85
Inhibition of ERK, not JNK, Signaling Improves Barrier Function in 2CLP Monolayers
Negative_regulation (Inhibition) of Neg (not) Gene_expression (not) of ERK
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0 Pain Relevance 0
Sustained inhibition of ERK expression leads to the induction of apoptosis in rat neuronal PC12 cells [15].
Negative_regulation (inhibition) of Gene_expression (expression) of ERK in neuronal associated with apoptosis
10) Confidence 0.25 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.78 Pain Relevance 0.10
Immunohistochemical methodology was employed to evaluate the expression levels of pc-Jun, c-Fos, JNK2, p-JNK, p-ERK and Runx2 due to alteration in functional load.
Negative_regulation (evaluate) of Gene_expression (expression) of ERK
11) Confidence 0.24 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041628 Disease Relevance 0.37 Pain Relevance 0.37
Our results represent the inhibitory effects of alagebrium on ERK activation and COX-2 inhibition (Fig. 3).
Negative_regulation (inhibition) of Gene_expression (activation) of ERK
12) Confidence 0.24 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.69 Pain Relevance 0
SL327, an inhibitor of ERK activation, at doses which reduced the hyperactive pERK(1/2) levels, did not attenuated the rise in pCREB and TH immunoreactivity or plasma corticosterone secretion during morphine withdrawal, indicating that ERK kinase/ERK pathway was not directly needed for either activation of CREB and TH expression in the NTS or HPA axis hyperactivity.
Negative_regulation (reduced) of Gene_expression (levels) of pERK in plasma associated with attention deficit hyperactivity disorder, withdrawal and morphine
13) Confidence 0.21 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.23 Pain Relevance 1.21
PF could similarly inhibit CRD-evoked p-ERK and c-Fos expression in laminae I-II of the lumbosacral dorsal horn and anterior cingulate cortex (ACC).
Negative_regulation (inhibit) of Gene_expression (expression) of ERK in ACC associated with dorsal horn and anterior cingulate cortex
14) Confidence 0.20 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19664651 Disease Relevance 0.49 Pain Relevance 1.19
PF could also reverse the CRD-evoked increased glutamate concentration by CRD as shown by dynamic microdialysis monitoring in ACC, whereas, DPCPX, an antagonist of adenosine A(1) receptor, significantly blocked the analgesic effect of PF and PF's inhibition on CRD-induced p-ERK and p-CREB expression.
Negative_regulation (reverse) of Gene_expression (expression) of ERK in ACC associated with adenocard, glutamate, analgesic, antagonist and anterior cingulate cortex
15) Confidence 0.20 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19664651 Disease Relevance 0.46 Pain Relevance 1.29
Further, rats given intra-LA infusion of c-PTIO exhibit a significant decrease in ERK phosphorylation and ERK-driven gene expression in the MGm/PIN, but not in the LA [44].
Negative_regulation (decrease) of Gene_expression (expression) of ERK associated with amygdala
16) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.30 Pain Relevance 0.53
Further, rats given intra-LA infusion of c-PTIO exhibit a significant decrease in ERK phosphorylation and ERK-driven gene expression in the MGm/PIN, but not in the LA [44].
Negative_regulation (decrease) of Gene_expression (expression) of ERK-driven associated with amygdala
17) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.30 Pain Relevance 0.53
A significant decrease in the expression of phosphorylated ERK 1/2 of thoracic aorta in 28-days diabetes group but not in 14-days diabetes group was observed as compared to control group.
Negative_regulation (decrease) of Gene_expression (expression) of ERK in thoracic aorta associated with diabetes mellitus
18) Confidence 0.14 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.27 Pain Relevance 0.12

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