INT128922

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.93
Pain Relevance 5.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
hepatocyte 3
DRG 2
liver 1
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 28 100.00 Very High Very High Very High
Spinal nerve ligature 7 100.00 Very High Very High Very High
Kinase C 42 99.84 Very High Very High Very High
dorsal root ganglion 6 99.20 Very High Very High Very High
Snapping jaw 4 97.68 Very High Very High Very High
Analgesic 5 97.04 Very High Very High Very High
Neuropathic pain 8 89.68 High High
Pain 2 82.60 Quite High
Lasting pain 2 74.64 Quite High
adenocard 2 70.72 Quite High
Disease Link Frequency Relevance Heat
Injury 20 99.82 Very High Very High Very High
Ganglion Cysts 6 99.20 Very High Very High Very High
Temporomandibular Joint Syndrome 4 97.68 Very High Very High Very High
Overdose 2 94.16 High High
Neuropathic Pain 9 89.68 High High
Poisoning 20 89.08 High High
Hepatotoxicity 34 88.04 High High
Pain 4 82.60 Quite High
Stress 38 73.60 Quite High
Death 27 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we found that preemptive edaravone treatment can reduce the SNL-induced pJNK expression in the ipsilateral DRG.
Negative_regulation (reduce) of Gene_expression (expression) of pJNK in DRG associated with dorsal root ganglion and spinal nerve ligature
1) Confidence 0.34 Published 2009 Journal Brain Res. Section Abstract Doc Link 19028459 Disease Relevance 1.45 Pain Relevance 1.85
Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection.
Negative_regulation (inhibition) of Gene_expression (bioactivation) of JNK in hepatocyte associated with paracetamol and injury
2) Confidence 0.26 Published 2010 Journal Free Radic. Biol. Med. Section Title Doc Link 19969075 Disease Relevance 0.66 Pain Relevance 0.91
Immunohistochemical methodology was employed to evaluate the expression levels of pc-Jun, c-Fos, JNK2, p-JNK, p-ERK and Runx2 due to alteration in functional load.
Negative_regulation (evaluate) of Gene_expression (expression) of JNK
3) Confidence 0.22 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041628 Disease Relevance 0.37 Pain Relevance 0.37
Furthermore, the decreased JNK activity by the specific inhibitor of PKC?
Negative_regulation (inhibitor) of Gene_expression (activity) of JNK associated with kinase c
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.40 Pain Relevance 0.66
Furthermore, the decreased JNK activity by the specific inhibitor of PKC?
Negative_regulation (decreased) of Gene_expression (activity) of JNK associated with kinase c
5) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.40 Pain Relevance 0.66
Inhibition of ERK, not JNK, Signaling Improves Barrier Function in 2CLP Monolayers
Negative_regulation (Inhibition) of Neg (not) Gene_expression (not) of JNK
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0 Pain Relevance 0
Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection.
Negative_regulation (inhibition) of in liver Gene_expression (bioactivation) of JNK in hepatocyte associated with paracetamol and injury
7) Confidence 0.09 Published 2010 Journal Free Radic. Biol. Med. Section Title Doc Link 19969075 Disease Relevance 0.66 Pain Relevance 0.91

General Comments

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