INT128925

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k7) nucleus (Map2k7) response to stress (Map2k7)
cytoplasm (Map2k7)
Anatomy Link Frequency
hepatocytes 1
Map2k7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 4 97.68 Very High Very High Very High
cytokine 3 97.36 Very High Very High Very High
anesthesia 1 95.00 High High
Inflammation 2 87.12 High High
Inflammatory response 1 25.40 Quite Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 4 97.68 Very High Very High Very High
INFLAMMATION 3 87.12 High High
Cancer 1 66.08 Quite High
Necrosis 1 65.84 Quite High
Sepsis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation.
Negative_regulation (suppressing) of MAPK/ERK in hepatocytes associated with cytokine
1) Confidence 0.10 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 18387647 Disease Relevance 0.29 Pain Relevance 0.32
Immunohistochemical methodology was employed to evaluate the expression levels of pc-Jun, c-Fos, JNK2, p-JNK, p-ERK and Runx2 due to alteration in functional load.
Negative_regulation (evaluate) of JNK2
2) Confidence 0.02 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041628 Disease Relevance 0.37 Pain Relevance 0.37

General Comments

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