INT128926

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.01
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k7) nucleus (Map2k7) response to stress (Map2k7)
cytoplasm (Map2k7)
Anatomy Link Frequency
sciatic nerves 2
amygdala 1
Map2k7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 12 98.76 Very High Very High Very High
Neuritis 16 98.36 Very High Very High Very High
Snapping jaw 8 97.16 Very High Very High Very High
amygdala 12 95.08 Very High Very High Very High
Inflammation 5 76.08 Quite High
Hippocampus 22 73.96 Quite High
nMDA receptor 5 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Visceral pain 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 16 98.36 Very High Very High Very High
Temporomandibular Joint Syndrome 8 97.16 Very High Very High Very High
Immunization 8 95.48 Very High Very High Very High
Stress 67 87.28 High High
INFLAMMATION 5 76.08 Quite High
Apoptosis 3 60.24 Quite High
Depression 4 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both P-JNK1 and P-JNK2/3 were significantly elevated in all brain areas, with the single exception of a non-significant increase in P-JNK1 in the amygdala (Fig. 4).
Gene_expression (/) of JNK2 in amygdala associated with amygdala
1) Confidence 0.23 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.29 Pain Relevance 0.14
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Gene_expression (expression) of JNK2 in sciatic nerves associated with immunization, sciatic nerve and neuritis
2) Confidence 0.06 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 1.00 Pain Relevance 0.72
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Gene_expression (expression) of JNK2 in sciatic nerves associated with immunization, sciatic nerve and neuritis
3) Confidence 0.06 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 0.99 Pain Relevance 0.72
Immunohistochemical methodology was employed to evaluate the expression levels of pc-Jun, c-Fos, JNK2, p-JNK, p-ERK and Runx2 due to alteration in functional load.
Gene_expression (expression) of JNK2
4) Confidence 0.03 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041628 Disease Relevance 0.36 Pain Relevance 0.36
Immunohistochemical methodology was employed to evaluate the expression levels of pc-Jun, c-Fos, JNK2, p-JNK, p-ERK and Runx2 due to alteration in functional load.
Gene_expression (levels) of JNK2
5) Confidence 0.02 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041628 Disease Relevance 0.36 Pain Relevance 0.36

General Comments

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