INT128936

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.08
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGER3) cell death (PTGER3) plasma membrane (PTGER3)
biological_process (PTGER3) signal transducer activity (PTGER3)
Anatomy Link Frequency
tail 6
HT-29 2
neurons 2
articular cartilage 2
PTGER3 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 37 99.78 Very High Very High Very High
Osteoarthritis 39 98.52 Very High Very High Very High
metalloproteinase 18 95.04 Very High Very High Very High
tetrodotoxin 2 90.56 High High
Arthritis 2 88.12 High High
antagonist 85 83.28 Quite High
agonist 135 82.16 Quite High
long-term potentiation 1 77.36 Quite High
Inflammation 28 75.72 Quite High
Hippocampus 4 74.68 Quite High
Disease Link Frequency Relevance Heat
Hypertrophy 44 99.12 Very High Very High Very High
Uterine Fibroids 216 99.08 Very High Very High Very High
Osteoarthritis 51 98.52 Very High Very High Very High
Cancer 90 96.96 Very High Very High Very High
Colon Cancer 323 93.60 High High
Disease 20 91.64 High High
Arthritis 5 88.12 High High
Bordatella Infection 20 79.36 Quite High
INFLAMMATION 45 75.72 Quite High
Adenocarcinoma 14 72.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to the fact that both of these responses downstream from these receptors are integral to muscular hypertrophy, we chose to examine if AA supplementation increased the expression of the FP and EP3 receptors.
Positive_regulation (increased) of Gene_expression (expression) of EP3 associated with hypertrophy
1) Confidence 0.67 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2217562 Disease Relevance 0.30 Pain Relevance 0
Removal of serum leads to the induction of EP3 expression whereas EP3 was virtually undetectable in cells kept in serum.
Positive_regulation (induction) of Gene_expression (expression) of EP3
2) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.38 Pain Relevance 0.04
As shown in Fig. 7B serum withdrawal gradually induced the expression of EP3.
Positive_regulation (induced) of Gene_expression (expression) of EP3 associated with withdrawal
3) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0.18
Pharmacological manipulation of EP receptor isoforms confirms a role for EP3/cAMP signalling in PGE2-dependent HT-29 cell proliferation
Positive_regulation (role) of Gene_expression (cAMP) of EP3 in HT-29
4) Confidence 0.32 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.08 Pain Relevance 0.19
Importantly, EP3 expression was detectable as early as 24 h after serum removal, that is, precisely the conditions used for cAMP signalling analysis and proliferation assays.
Positive_regulation (detectable) of Gene_expression (expression) of EP3
5) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0.17
Alternative splicing generates three isoforms: EP3 alpha, EP3 beta and EP3 gamma, which differ in the putative cytoplasmic carboxy-terminal tail.
Positive_regulation (generates) of Gene_expression (generates) of EP3 in tail
6) Confidence 0.30 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.50 Pain Relevance 0
Alternative splicing generates three isoforms: EP3 alpha, EP3 beta and EP3 gamma, which differ in the putative cytoplasmic carboxy-terminal tail.
Positive_regulation (generates) of Gene_expression (generates) of EP3 in tail
7) Confidence 0.30 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.50 Pain Relevance 0
Alternative splicing generates three isoforms: EP3 alpha, EP3 beta and EP3 gamma, which differ in the putative cytoplasmic carboxy-terminal tail.
Positive_regulation (generates) of Gene_expression (generates) of EP3 in tail
8) Confidence 0.30 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.50 Pain Relevance 0
Overexpression of heterologous HA-tagged human EP3 subtype 3 prior to RT-PCR analysis was perfomed to discriminate subtypes 2 and 3.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of EP3 subtype 3
9) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0.06
Our own preliminary data on receptor involvement suggest a role of EP3 receptor, which expression is significantly upregulated on the addition of 10 pg/ml PGE2 to OA articular cartilage explants (E.V.
Positive_regulation (upregulated) of Gene_expression (expression) of EP3 receptor in articular cartilage associated with osteoarthritis
10) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.58 Pain Relevance 0.26
As FPS cells also express basal levels of EP2 and EP4 receptor (but not detectable EP1 or EP3 receptor), we found that PGE2 and to a much lesser extent PGF2?
Positive_regulation (levels) of Gene_expression (receptor) of EP3
11) Confidence 0.05 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.24 Pain Relevance 0.19
The expressions of EP 2, EP 4, and EP 3 were further elevated or reduced in neurons treated with high K(+) for 24 hr.
Positive_regulation (elevated) of Gene_expression (expressions) of EP 3 in neurons
12) Confidence 0.01 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16041798 Disease Relevance 0 Pain Relevance 0.36

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