INT128937

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.49
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGER3) cell death (PTGER3) plasma membrane (PTGER3)
biological_process (PTGER3) signal transducer activity (PTGER3)
Anatomy Link Frequency
eosinophil 2
muscle 1
neurons 1
nasal 1
PTGER3 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 99.00 Very High Very High Very High
Inflammation 105 96.52 Very High Very High Very High
agonist 6 94.64 High High
long-term potentiation 1 85.12 High High
Hippocampus 4 74.56 Quite High
cytokine 8 72.48 Quite High
cerebral cortex 1 67.40 Quite High
Paracetamol 3 65.04 Quite High
Inflammatory stimuli 9 60.32 Quite High
aspirin 25 54.88 Quite High
Disease Link Frequency Relevance Heat
Nasal Polyps 72 99.68 Very High Very High Very High
Chronic Sinusitis 72 98.58 Very High Very High Very High
INFLAMMATION 127 96.52 Very High Very High Very High
Rhinitis 48 96.00 Very High Very High Very High
Disease 51 95.56 Very High Very High Very High
Polyps 9 91.84 High High
Uterine Fibroids 72 91.04 High High
Disorders Of Creatine Metabolism 1 80.48 Quite High
Cancer 29 72.40 Quite High
Phosphate Metabolism Disorders 55 66.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also observed that EP2 and EP4 receptors are up-regulated in chronic rhinosinusitis and nasal polyp tissue compared to control subjects; however, EP1 and EP3 transcripts were statistically decreased in the nasal polyp patients.
Negative_regulation (decreased) of EP3 in nasal associated with chronic sinusitis and nasal polyps
1) Confidence 0.23 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.51 Pain Relevance 0.24
Eicosanoid receptors mRNA pattern observed in our patient's groups suggest that down-regulation of EP1 and EP3 in the nasal polyp tissue and up-regulation EP2 and EP4 in both chronic rhinosinusitis groups may play a role in the development of the diseases and their regulation do not directly depend of eosinophil activation.
Negative_regulation (regulation) of EP3 in eosinophil associated with chronic sinusitis, nasal polyps and disease
2) Confidence 0.17 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.33 Pain Relevance 0.11
Eicosanoid receptors mRNA pattern observed suggests that down-regulation of EP1 and EP3 in CRS-NP and up-regulation EP2 and EP4 in CRS and CRS-NP groups may have some role in the development of the diseases and their regulation may not be directly linked to eosinophil activation but involve post-transcriptional events mainly related to other inflammatory cell sources.



Negative_regulation (down-regulation) of EP3 in eosinophil associated with inflammation and disease
3) Confidence 0.17 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1481584 Disease Relevance 0.70 Pain Relevance 0.13
It was demonstrated that while EP3 gamma is coupled to both stimulation and inhibition of adenylate cyclase, EP3 alpha and beta are exclusively coupled to inhibition of adenylate cyclase [43].
Negative_regulation (inhibition) of EP3
4) Confidence 0.15 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.55 Pain Relevance 0
A significant reduction of systemic PGE-M levels, which were elevated in four out of five pre-treatment periods, was noted (figure 4) (Mann Whitney's exact U-Test: p = 0.016).
Negative_regulation (reduction) of PGE-M
5) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.20 Pain Relevance 0
PGE2 exerts its autocrine/paracrine action by binding to either of four main subtypes of GPCR (EP1, EP2, EP3 and EP4) to mobilize intracellular calcium and inositol 1,4,5-trisphosphate (InsP) via Gq/11 (EP1/EP3) or increase cAMP accumulation via G?
Negative_regulation (subtypes) of EP3
6) Confidence 0.02 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.13 Pain Relevance 0.13
However, mRNA of EP 3 was down-regulated in neurons treated with tetrodotoxin or MK-801 plus DNQX for 24 hr.
Negative_regulation (down-regulated) of EP 3 in neurons associated with tetrodotoxin
7) Confidence 0.01 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16041798 Disease Relevance 0 Pain Relevance 0.36
Table 4 presents muscle protein content, MHC fiber protein content, MHC mRNA expression, and FP and EP3 receptor levels observed for each group in response to training.
Negative_regulation (presents) of EP3 receptor in muscle
8) Confidence 0.00 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2217562 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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