INT128987

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Context Info
Confidence 0.52
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 15.78
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
leucocytes 1
lungs 1
MDA-MB-231 1
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 27 97.68 Very High Very High Very High
Inflammation 37 96.16 Very High Very High Very High
cINOD 30 95.68 Very High Very High Very High
agonist 55 95.28 Very High Very High Very High
chemokine 3 82.56 Quite High
cytokine 11 81.44 Quite High
ischemia 2 80.88 Quite High
Inflammatory response 4 75.00 Quite High
antagonist 2 67.04 Quite High
Chronic pancreatitis 4 65.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 954 100.00 Very High Very High Very High
Repression 35 100.00 Very High Very High Very High
Neurofibromatosis 2 9 99.56 Very High Very High Very High
Apoptosis 203 98.88 Very High Very High Very High
Breast Cancer 27 98.38 Very High Very High Very High
Hyperplasia 19 97.72 Very High Very High Very High
Colitis 2 96.36 Very High Very High Very High
INFLAMMATION 49 96.16 Very High Very High Very High
Ataxia 3 93.80 High High
Colon Cancer 55 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with this reduction in proliferation rate, the proliferation markers c-Myc and cyclin D1 were decreased (Fig. 1E).
Negative_regulation (decreased) of cyclin D1
1) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.39 Pain Relevance 0
In agreement with their reduction in proliferation rate, the proliferation markers c-Myc and cyclin D1 were decreased.
Negative_regulation (decreased) of cyclin D1
2) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.18 Pain Relevance 0
Indeed loss of Cyclin D1 in over-expressing miR-199b-5p clones are a reminder of the similar effects seen in Ccnd1–/– mice, which have decreased early GNP proliferation and early ataxia as a consequence of a delay in acquiring normal cerebellar function, thus affecting progression of the pre-neoplastic lesions to MBs [43].
Negative_regulation (loss) of Cyclin D1 associated with ataxia and cancer
3) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.39 Pain Relevance 0
In addition, Sox17 counteracted repression of the cyclin D1 promoter by TGF-?
Negative_regulation (repression) of cyclin D1 associated with repression
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.19 Pain Relevance 0
/Smad3-mediated repression of cyclin D1 also contributes to its increased expression in CCSPrtTA/tetO-Sox17 mouse lungs.
Negative_regulation (repression) of cyclin D1 in lungs associated with repression
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.19 Pain Relevance 0
C-DIMs inhibit breast cancer cell proliferation; however, inhibition of G(0)/G(1) to S phase progression and cyclin D1 downregulation was observed in MDA-MB-231 but not MDA-MB-453 cells.
Negative_regulation (downregulation) of cyclin D1 in MDA-MB-231 associated with breast cancer
6) Confidence 0.31 Published 2008 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 17624585 Disease Relevance 0.47 Pain Relevance 0.13
Lumican significantly suppressed subcutaneous tumor formation in syngenic mice, with a concomitant decrease in cyclin D1 expression level, and induced and/or enhanced the apoptosis of these cells.
Negative_regulation (decrease) of cyclin D1 associated with cancer and apoptosis
7) Confidence 0.25 Published 2005 Journal J Nippon Med Sch Section Abstract Doc Link 16046829 Disease Relevance 1.24 Pain Relevance 0.08
of this inhibition is a decrease in cyclin D1, the binding partner
Negative_regulation (decrease) of cyclin D1
8) Confidence 0.19 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.11 Pain Relevance 0.13
tumors through a reduction of cyclin D1 and HB-EGF [54] and an increase of p27Kip1 [55–57].
Negative_regulation (reduction) of cyclin D1 associated with cancer
9) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 1.13 Pain Relevance 0.20
Despite the increased mRNA level, cyclin D1 protein levels were downregulated.
Negative_regulation (downregulated) of cyclin D1
10) Confidence 0.17 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17546589 Disease Relevance 0.56 Pain Relevance 0.27
Cyclin D1, E and A associated kinase activities decreased by four-, four-, and fivefold, respectively, in TM10 cells compared with control on SAHA treatment, whereas only cyclin D1 and A associated kinase activities decreased (2.2- and 2.6-fold, respectively) in SAHA treated TM2H cells compared with control (Fig. 6).
Negative_regulation (decreased) of cyclin D1
11) Confidence 0.16 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0 Pain Relevance 0
of CDK4 in G1, by depletion of cyclin D1 mRNA resulting in a
Negative_regulation (depletion) of cyclin D1
12) Confidence 0.14 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.16 Pain Relevance 0.12
It has been shown previously that NF2 expression induces a decrease in cyclin D1 and CDK4 kinase activity, concomitant with dephosphorylation of pRB and reduced DNA synthesis (9, 28).
Negative_regulation (decrease) of cyclin D1 associated with neurofibromatosis 2
13) Confidence 0.13 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.17 Pain Relevance 0.03
In contrast, VPA showed a gradual decrease in cyclin D1 level.


Negative_regulation (decrease) of cyclin D1
14) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.25 Pain Relevance 0
-tubulin, and p21WAF1 levels accompanied by upregulation of p27, caspase 3, and caspase 9, and downregulation of bcl-2, cyclin D1, and survivin.
Negative_regulation (downregulation) of cyclin D1
15) Confidence 0.10 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2994814 Disease Relevance 0.60 Pain Relevance 0
expression levels of c-myc, cyclin D1
Negative_regulation (levels) of cyclin D1
16) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.38 Pain Relevance 0
Exposure to reg4 antibody resulted in a significant decrease in intra-tumor levels of pAkt, Bcl-xL, Bcl-2, survivin and cyclin D1.


Negative_regulation (decrease) of cyclin D1 associated with cancer
17) Confidence 0.08 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2760775 Disease Relevance 1.01 Pain Relevance 0
However, our results could be explained, at least in part, by the fact that levels of the antiapoptotic-associated proteins such as activated AKT, Bcl-2, Bcl-xL and surviving, as well as the cell cycle-associated protein cyclin D1, were strongly decreased (Figure 7) indicating that apoptosis and cell cycle are regulated by reg4.
Negative_regulation (decreased) of cyclin D1 associated with apoptosis
18) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 0.89 Pain Relevance 0
Reduced cyclin D1 protein level
Negative_regulation (Reduced) of cyclin D1
19) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.24 Pain Relevance 0
The effect of EGFR inhibition on target genes cyclin-D1, c-myc was evaluated at the RNA level (figure 7).
Negative_regulation (inhibition) of cyclin-D1
20) Confidence 0.08 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 0.78 Pain Relevance 0

General Comments

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