INT128993

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
neurons 2
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
conotoxin 2 99.36 Very High Very High Very High
Kinase C 6 98.68 Very High Very High Very High
Calcium channel 2 98.32 Very High Very High Very High
dorsal root ganglion 10 96.88 Very High Very High Very High
Hyperalgesia 2 93.04 High High
chemokine 8 87.08 High High
Inflammation 2 79.68 Quite High
Pain 2 61.04 Quite High
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Bordatella Infection 2 98.40 Very High Very High Very High
Ganglion Cysts 10 96.88 Very High Very High Very High
Hyperalgesia 2 93.04 High High
INFLAMMATION 2 79.68 Quite High
Nociception 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CGRP release by CCL2 and CXCL1 was significantly inhibited by EGTA, omega-conotoxin GVIA (an N-type calcium channel blocker), thapsigargin, and ryanodine.
Negative_regulation (inhibited) of Localization (release) of CCL2 associated with calcium channel, conotoxin and calcitonin gene-related peptide
1) Confidence 0.42 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.72 Pain Relevance 0.97
Pretreatment of DRG neurons for 30 min with the inhibitors of phospholipase C (PLC) and protein kinase C (PKC) but not mitogen-activated protein kinases (MAPKs) significantly reduced CCL2- or CXCL1-induced CGRP release and intracellular calcium elevation.
Negative_regulation (reduced) of Localization (release) of CCL2 in neurons associated with dorsal root ganglion, kinase c and calcitonin gene-related peptide
2) Confidence 0.41 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.78 Pain Relevance 1.13

General Comments

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