INT128996

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.43
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2, Calca) aging (Ccl2, Calca) extracellular region (Ccl2, Calca)
cytoplasm (Ccl2, Calca) nucleus (Calca) intracellular (Calca)
Anatomy Link Frequency
neurons 2
Ccl2 (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
dorsal root ganglion 10 98.40 Very High Very High Very High
Hyperalgesia 2 97.12 Very High Very High Very High
Kinase C 6 95.28 Very High Very High Very High
chemokine 8 93.24 High High
conotoxin 2 87.20 High High
Inflammation 2 85.84 High High
Calcium channel 2 85.12 High High
Pain 2 78.00 Quite High
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 10 98.40 Very High Very High Very High
Bordatella Infection 2 98.32 Very High Very High Very High
Hyperalgesia 2 97.12 Very High Very High Very High
INFLAMMATION 2 85.84 High High
Nociception 6 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that CCL2 and CXCL1 can stimulate CGRP release and intracellular calcium elevation in DRG neurons.
CCL2 Positive_regulation (stimulate) of Localization (release) of CGRP in neurons associated with dorsal root ganglion and calcitonin gene-related peptide
1) Confidence 0.68 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.76 Pain Relevance 1.13
The results showed that CCL2 and CXCL1 ( approximately 5-100 ng/ml) evoked CGRP release and intracellular calcium elevation in a pertussis toxin (PTX)-sensitive manner.
CCL2 Positive_regulation (evoked) of Localization (release) of CGRP associated with bordatella infection and calcitonin gene-related peptide
2) Confidence 0.49 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.67 Pain Relevance 0.87

General Comments

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