INT128998

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.96
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1, Calca) extracellular region (Cxcl1, Calca) aging (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
neurons 6
Cxcl1 (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 40 100.00 Very High Very High Very High
dorsal root ganglion 20 98.40 Very High Very High Very High
Kinase C 12 98.34 Very High Very High Very High
chemokine 16 98.24 Very High Very High Very High
Pain 4 97.48 Very High Very High Very High
Hyperalgesia 4 96.76 Very High Very High Very High
Calcium channel 4 90.72 High High
conotoxin 4 89.44 High High
Inflammation 4 85.48 High High
nociceptor 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 12 99.44 Very High Very High Very High
Ganglion Cysts 20 98.40 Very High Very High Very High
Bordatella Infection 4 98.32 Very High Very High Very High
Hyperalgesia 4 96.76 Very High Very High Very High
INFLAMMATION 4 85.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of DRG neurons for 30 min with the inhibitors of phospholipase C (PLC) and protein kinase C (PKC) but not mitogen-activated protein kinases (MAPKs) significantly reduced CCL2- or CXCL1-induced CGRP release and intracellular calcium elevation.
CXCL1 Positive_regulation (induced) of Localization (release) of CGRP in neurons associated with dorsal root ganglion, kinase c and calcitonin gene-related peptide
1) Confidence 0.66 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.77 Pain Relevance 1.13
These data suggest that CCL2 and CXCL1 can stimulate CGRP release and intracellular calcium elevation in DRG neurons.
CXCL1 Positive_regulation (stimulate) of Localization (release) of CGRP in neurons associated with dorsal root ganglion and calcitonin gene-related peptide
2) Confidence 0.66 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.76 Pain Relevance 1.12
PLC-, PKC-, and calcium-induced calcium release from ryanodine-sensitive calcium stores signaling pathways are involved in CCL2- and CXCL1-induced CGRP release from primary nociceptive neurons, in which chemokines produce painful effects via direct actions on chemokine receptors expressed by nociceptive neurons.
CXCL1 Positive_regulation (induced) of Localization (release) of CGRP in neurons associated with nociception, pain, chemokine, kinase c and calcitonin gene-related peptide
3) Confidence 0.48 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.76 Pain Relevance 1.03
The results showed that CCL2 and CXCL1 ( approximately 5-100 ng/ml) evoked CGRP release and intracellular calcium elevation in a pertussis toxin (PTX)-sensitive manner.
CXCL1 Positive_regulation (evoked) of Localization (release) of CGRP associated with bordatella infection and calcitonin gene-related peptide
4) Confidence 0.48 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.67 Pain Relevance 0.87

General Comments

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