INT129

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Context Info
Confidence 0.80
First Reported 1976
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 51
Total Number 52
Disease Relevance 11.08
Pain Relevance 15.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OXTR) signal transducer activity (OXTR)
Anatomy Link Frequency
plasma 6
brain 4
uterine 3
blood 2
anterior 1
OXTR (Homo sapiens)
Pain Link Frequency Relevance Heat
epidural 166 100.00 Very High Very High Very High
Neuropeptide 18 100.00 Very High Very High Very High
Endogenous opioid 13 100.00 Very High Very High Very High
Catecholamine 5 100.00 Very High Very High Very High
Somatostatin 4 99.98 Very High Very High Very High
opiate 13 99.90 Very High Very High Very High
Opioid 53 99.68 Very High Very High Very High
narcan 16 99.68 Very High Very High Very High
analgesia 137 99.52 Very High Very High Very High
local anesthetic 39 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 192 100.00 Very High Very High Very High
Labor Pain 9 99.14 Very High Very High Very High
Hypoglycemia 10 99.04 Very High Very High Very High
INFLAMMATION 62 98.68 Very High Very High Very High
Pre-term Labor 37 98.68 Very High Very High Very High
Dysmenorrhea 36 98.10 Very High Very High Very High
Apoptosis 11 97.80 Very High Very High Very High
Disease 45 96.28 Very High Very High Very High
Premature Birth 144 92.16 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The study of the interaction between exogenously administered opiates and oxytocin secretion may give insight into the activity of any opiate-mediated regulatory mechanism of oxytocin secretion in the fetus.
Localization (secretion) of oxytocin associated with opiate
1) Confidence 0.80 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9662490 Disease Relevance 0.05 Pain Relevance 0.84
The study of the interaction between exogenously administered opiates and oxytocin secretion may give insight into the activity of any opiate-mediated regulatory mechanism of oxytocin secretion in the fetus.
Localization (secretion) of oxytocin associated with opiate
2) Confidence 0.80 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9662490 Disease Relevance 0 Pain Relevance 0.80
Uterine contractions in labour are influenced by endogenous substances such as oestrogens, progesterone, cortisol, oxytocin, prostaglandins, relaxin, adrenergic and cholinergic secretions, cyclic nucleotides and calcium ions.
Localization (secretions) of oxytocin in Uterine associated with dismenorea
3) Confidence 0.80 Published 1991 Journal Ann. Acad. Med. Singap. Section Abstract Doc Link 2029168 Disease Relevance 0.22 Pain Relevance 0.25
Presently, there is little evidence for an increased maternal secretion rate of oxytocin at the onset of labor, but during labor a progressive increase occurs, with a maximum at the expulsive phase.
Localization (rate) of oxytocin
4) Confidence 0.80 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0.05
Evidence from oxytocin receptor blockade and suppression of oxytocin secretion supports the concept that oxytocin is an important stimulus for uterine contractions in early human labor.
Localization (secretion) of oxytocin in uterine associated with dismenorea
5) Confidence 0.80 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0.10 Pain Relevance 0.10
Hence, an increased oxytocin secretion rate is not a necessary prerequisite for oxytocin-stimulated contractions during labor.
Localization (secretion) of oxytocin
6) Confidence 0.80 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0.08
It is concluded that oxytocin is secreted in short-lasting spurts; therefore levels measured with infrequent intervals do not give adequate information on the amounts of oxytocin secreted during labor.
Localization (secreted) of oxytocin
7) Confidence 0.80 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0
It is concluded that oxytocin is secreted in short-lasting spurts; therefore levels measured with infrequent intervals do not give adequate information on the amounts of oxytocin secreted during labor.
Localization (secreted) of oxytocin
8) Confidence 0.80 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0
Both epidural local anesthetics and intrathecal opioid reduce some parameters of the neuroendocrine response to labor pain and the reflex release of oxytocin in animals.
Localization (release) of oxytocin associated with epidural, pain labor, opioid and intrathecal
9) Confidence 0.80 Published 2001 Journal Reg Anesth Pain Med Section Abstract Doc Link 11707794 Disease Relevance 0.10 Pain Relevance 0.93
This permits the identification of four possible points of attack: (1) replacement of progesterone to reduce the myometrial sensitivity to oxytocin, (2) administration of beta-mimetic agents to relax the uterus and make it unresponsive to stimuli, (3) administration of ethanol to block oxytocin secretion, and (4) administration of anti-inflammatory drugs to inhibit prostaglandin synthesis.
Localization (secretion) of oxytocin in uterus associated with inflammation and cinod
10) Confidence 0.80 Published 1976 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 11689 Disease Relevance 0.10 Pain Relevance 0.10
The results indicated that oxytocin is secreted in discrete pulses of short duration.
Localization (secreted) of oxytocin
11) Confidence 0.80 Published 1991 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 1957888 Disease Relevance 0 Pain Relevance 0
Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women.
Localization (secretion) of Oxytocin
12) Confidence 0.80 Published 1991 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 1957888 Disease Relevance 0.05 Pain Relevance 0.05
The secretory pattern of oxytocin was determined in blood samples taken at 1-minute intervals for 30 minutes from 32 parturient women.
Localization (secretory) of oxytocin in blood
13) Confidence 0.74 Published 1991 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 1957888 Disease Relevance 0 Pain Relevance 0
Although ineffective when given alone, opioids potentiate the release of oxytocin in the limbic brain and increase the intensity of maternal responding, while the opioid receptor blocker, naltrexone, prevents both maternal induction and oxytocin release.
Localization (release) of oxytocin in brain associated with opioid receptor and opioid
14) Confidence 0.72 Published 1994 Journal Acta Paediatr Suppl Section Abstract Doc Link 7981474 Disease Relevance 0 Pain Relevance 0.18
Vaginocervical stimulation increases the release of oxytocin into cerebrospinal fluid and in-vivo microdialysis has revealed high levels of oxytocin release in limbic brain areas known to be important for maternal behaviour.
Localization (release) of oxytocin in brain
15) Confidence 0.72 Published 1994 Journal Acta Paediatr Suppl Section Abstract Doc Link 7981474 Disease Relevance 0 Pain Relevance 0.16
Although ineffective when given alone, opioids potentiate the release of oxytocin in the limbic brain and increase the intensity of maternal responding, while the opioid receptor blocker, naltrexone, prevents both maternal induction and oxytocin release.
Localization (release) of oxytocin in brain associated with opioid receptor and opioid
16) Confidence 0.72 Published 1994 Journal Acta Paediatr Suppl Section Abstract Doc Link 7981474 Disease Relevance 0 Pain Relevance 0.19
Presently, there is little evidence for an increased maternal secretion rate of oxytocin at the onset of labor, but during labor a progressive increase occurs, with a maximum at the expulsive phase.
Localization (secretion) of oxytocin
17) Confidence 0.70 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0.05
Animal and human work has indicated that maternal oxytocin secretion is under the control of endogenous opiates.
Localization (secretion) of oxytocin associated with opiate
18) Confidence 0.70 Published 1998 Journal Clin. Sci. Section Abstract Doc Link 9662490 Disease Relevance 0 Pain Relevance 0.58
In humans, epidural local anesthetics only reduce the spurt release of oxytocin.
Localization (release) of oxytocin
19) Confidence 0.70 Published 2001 Journal Reg Anesth Pain Med Section Abstract Doc Link 11707794 Disease Relevance 0.09 Pain Relevance 0.91
Prostaglandin release</span> during induction of labor by oxytocin.
Localization (release) of Oxytocin
20) Confidence 0.68 Published 1981 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 6274193 Disease Relevance 0.13 Pain Relevance 0.13

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