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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.50
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
ganglia 2
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 74 100.00 Very High Very High Very High
Trk A 11 100.00 Very High Very High Very High
allodynia 41 97.40 Very High Very High Very High
substance P 10 85.04 High High
Thermal hyperalgesia 1 84.88 Quite High
Inflammation 21 79.44 Quite High
tolerance 2 78.96 Quite High
Pain 48 77.28 Quite High
Cancer pain 23 46.48 Quite Low
Analgesic 5 35.76 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 50 97.40 Very High Very High Very High
Apoptosis 1 90.88 High High
Hyperalgesia 10 84.88 Quite High
INFLAMMATION 29 79.44 Quite High
Pain 47 77.28 Quite High
Syndrome 4 75.60 Quite High
Disease Progression 4 68.32 Quite High
Cancer 56 60.88 Quite High
Sarcoma 8 59.68 Quite High
Neuroma 25 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we reported enhanced NGF expression and phosphorylation of Trk A receptors in LDRG of db/db mice during the period of mechanical allodynia.
Negative_regulation (reported) of Phosphorylation (phosphorylation) of Trk A associated with allodynia, nerve growth factor and trk a
1) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.38 Pain Relevance 0.76
NGF-induced phosphorylation of TrkA and mitogen-activated protein kinase was significantly diminished in the necdin-null sensory ganglia.
Negative_regulation (diminished) of Phosphorylation (phosphorylation) of TrkA in ganglia associated with nerve growth factor
2) Confidence 0.33 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16049186 Disease Relevance 0.39 Pain Relevance 0.32
ARRY-470 at a dose of 30 mg/kg in a mouse xenograft model derived from HEK cells constitutively expressing active human TrkA showed >90% inhibition of phosphorylated TrkA at 1 hour and >70% inhibition over a 12 hour time course [49].
Negative_regulation (inhibition) of Phosphorylation (phosphorylated) of TrkA
3) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.73 Pain Relevance 0.34

General Comments

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