INT129020

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Context Info
Confidence 0.80
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 5.97
Pain Relevance 6.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
nerve 1
ganglia 1
neurite 1
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Trk A 49 100.00 Very High Very High Very High
trk B 16 100.00 Very High Very High Very High
Nerve growth factor 307 99.82 Very High Very High Very High
allodynia 119 97.40 Very High Very High Very High
substance P 28 96.28 Very High Very High Very High
agonist 154 94.92 High High
Hsan 1 90.56 High High
Cold hyperalgesia 3 89.12 High High
Lasting pain 6 88.76 High High
ischemia 24 88.32 High High
Disease Link Frequency Relevance Heat
Apoptosis 270 99.00 Very High Very High Very High
Neuropathic Pain 148 97.40 Very High Very High Very High
Hypohidrosis 1 94.48 High High
Death 104 93.36 High High
Convulsion 20 91.20 High High
Neuroblastoma 18 90.92 High High
Hereditary Sensory And Autonomic Neuropathies 4 90.56 High High
Hyperalgesia 24 89.12 High High
Pain 93 88.76 High High
Cv Unclassified Under Development 16 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The consistent time course shared by p38 phosphorylation, NGF upregulation, and Trk A phosphorylation in LDRG strongly suggests that the NGF-Trk A/p38 pathway mediates mechanical allodynia in db/db mice [15].
Phosphorylation (phosphorylation) of Trk A associated with allodynia, nerve growth factor and trk a
1) Confidence 0.80 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.58 Pain Relevance 1.10
Previously, we reported enhanced NGF expression and phosphorylation of Trk A receptors in LDRG of db/db mice during the period of mechanical allodynia.
Phosphorylation (phosphorylation) of Trk A associated with allodynia, nerve growth factor and trk a
2) Confidence 0.79 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.38 Pain Relevance 0.76
NGF-induced phosphorylation of TrkA and mitogen-activated protein kinase was significantly diminished in the necdin-null sensory ganglia.
Phosphorylation (phosphorylation) of TrkA in ganglia associated with nerve growth factor
3) Confidence 0.63 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16049186 Disease Relevance 0.37 Pain Relevance 0.31
There are two potential signaling mechanisms that may underlie this effect: 1) NGF may directly induce Trk A-dependent p38 phosphorylation, or 2) NGF could indirectly activate interleukin 1-beta-dependent p38 activation to promote SP expression [36].
Phosphorylation (phosphorylation) of Trk A associated with nerve growth factor, trk a and substance p
4) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.59 Pain Relevance 1.13
ARRY-470 at a dose of 30 mg/kg in a mouse xenograft model derived from HEK cells constitutively expressing active human TrkA showed >90% inhibition of phosphorylated TrkA at 1 hour and >70% inhibition over a 12 hour time course [49].
Phosphorylation (phosphorylated) of TrkA
5) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.73 Pain Relevance 0.34
Treatment of PC12 cells with a cell-permeable version of the leukocyte common antigen receptor (a tyrosine phosphatase), expressed in neurons, causes neurite outgrowth in a TrkA-dependent manner, presumably by preventing de-phosphorylation of TrkA [103].
Phosphorylation (phosphorylation) of TrkA in neurite
6) Confidence 0.51 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.16 Pain Relevance 0.15
This compound binds TrkA, but not TrkB or TrkC, and causes receptor dimerization and phosphorylation.
Phosphorylation (phosphorylation) of TrkA
7) Confidence 0.51 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.54 Pain Relevance 0.12
Mutations in the neurotrophic tyrosine kinase receptor type 1 (NTRK1), a receptor in the neurotrophin signaling pathway phosphorylated in response to nerve growth factor, are associated with this disorder.
Phosphorylation (phosphorylated) of NTRK1 in nerve associated with nerve growth factor
8) Confidence 0.35 Published 2008 Journal Neurogenetics Section Abstract Doc Link 18322713 Disease Relevance 0.53 Pain Relevance 0.14
Phosphorylated Trk A, Trk A, phosphorylated Trk B, and Trk B were detected using specific antibodies and Zymed Histo-SP AEC kit (Invitrogen, USA).
Phosphorylation (phosphorylated) of Trk associated with trk a and trk b
9) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.17 Pain Relevance 0.28
Phosphorylated Trk A, Trk A, phosphorylated Trk B, and Trk B were detected using specific antibodies and Zymed Histo-SP AEC kit (Invitrogen, USA).
Phosphorylation (Phosphorylated) of Trk associated with trk a and trk b
10) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.16 Pain Relevance 0.28
Phosphorylated Trk A, Trk A, phosphorylated Trk B, and Trk B were detected using specific antibodies and Zymed Histo-SP AEC kit (Invitrogen, USA).
Phosphorylation (Phosphorylated) of Trk associated with trk a and trk b
11) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.16 Pain Relevance 0.28
Phosphorylated Trk A, Trk A, phosphorylated Trk B, and Trk B were detected using specific antibodies and Zymed Histo-SP AEC kit (Invitrogen, USA).
Phosphorylation (phosphorylated) of Trk associated with trk a and trk b
12) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.16 Pain Relevance 0.28
Phosphorylated Trk A, Trk A, phosphorylated Trk B, and Trk B were detected using specific antibodies and Zymed Histo-SP AEC kit (Invitrogen, USA).
Phosphorylation (phosphorylated) of Trk associated with trk a and trk b
13) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.17 Pain Relevance 0.28
Phosphorylated Trk A, Trk A, phosphorylated Trk B, and Trk B were detected using specific antibodies and Zymed Histo-SP AEC kit (Invitrogen, USA).
Phosphorylation (phosphorylated) of Trk associated with trk a and trk b
14) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.16 Pain Relevance 0.28
Phosphorylated Trk A, Trk A, phosphorylated Trk B, and Trk B were detected using specific antibodies and Zymed Histo-SP AEC kit (Invitrogen, USA).
Phosphorylation (Phosphorylated) of Trk associated with trk a and trk b
15) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.17 Pain Relevance 0.28
Phosphorylated Trk A, Trk A, phosphorylated Trk B, and Trk B were detected using specific antibodies and Zymed Histo-SP AEC kit (Invitrogen, USA).
Phosphorylation (Phosphorylated) of Trk associated with trk a and trk b
16) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.17 Pain Relevance 0.28
Phosphorylation of Tyr785 of TrkA receptors determines, instead, activation of phospholipase C-?
Phosphorylation (Phosphorylation) of TrkA
17) Confidence 0.08 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.78 Pain Relevance 0.08

General Comments

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