INT129043

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.40
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Snrnp27) nucleus (Snrnp27) molecular_function (Snrnp27)
cellular_component (Snrnp27) biological_process (Snrnp27)
Snrnp27 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 10 99.16 Very High Very High Very High
Pain threshold 2 97.68 Very High Very High Very High
Central nervous system 2 97.24 Very High Very High Very High
Pain 2 96.08 Very High Very High Very High
agonist 2 80.92 Quite High
antagonist 2 80.72 Quite High
Analgesic 2 77.72 Quite High
Disease Link Frequency Relevance Heat
Pain 4 97.68 Very High Very High Very High
Hyperalgesia 2 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the stimulation of RyRs appears to play an important role in the increase of the pain threshold produced by physostigmine and oxotremorine in mice.
Positive_regulation (stimulation) of RyRs associated with pain threshold
1) Confidence 0.54 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 16051378 Disease Relevance 0.22 Pain Relevance 0.74
The role of ryanodine receptors (RyRs) in the induction of muscarinic antinociception was investigated in a condition of acute thermal pain by means of the mouse hot-plate test.
Spec (investigated) Positive_regulation (role) of RyRs associated with pain and antinociception
2) Confidence 0.34 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 16051378 Disease Relevance 0.18 Pain Relevance 0.44

General Comments

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