INT129074

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TCHP) signal transduction (GRP) extracellular space (GRP)
extracellular region (GRP) plasma membrane (TCHP) cytoskeleton (TCHP)
GRP (Homo sapiens)
TCHP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 62.84 Quite High
bradykinin 1 61.40 Quite High
substance P 1 60.92 Quite High
Disease Link Frequency Relevance Heat
Cancer 4 100.00 Very High Very High Very High
Malignant Neoplastic Disease 1 84.48 Quite High
Reprotox - General 1 1 81.92 Quite High
Natriuresis 1 60.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that the effects of NEP are mediated by its ability to catalytically inactivate substrates such as bombesin and endothelin-1, but also through direct protein-protein interaction with other protein such as Lyn kinase [which associates with the p85 subunit of phosphatidylinositol 3-kinase (PI3-K) resulting in NEP-Lyn-PI3-K protein complex], ezrin/radixin/moesin (ERM) proteins, and the PTEN tumor suppressor protein.
bombesin Binding (interaction) of PTEN tumor suppressor protein associated with cancer
1) Confidence 0.00 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16054017 Disease Relevance 0.50 Pain Relevance 0.12

General Comments

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