INT129099

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.20
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hbegf) extracellular region (Hbegf) plasma membrane (Hbegf)
Hbegf (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 98.70 Very High Very High Very High
agonist 4 98.14 Very High Very High Very High
opioid receptor 22 97.98 Very High Very High Very High
abdominal pain 4 96.30 Very High Very High Very High
Angina 1 80.64 Quite High
depression 1 78.80 Quite High
anesthesia 2 12.56 Low Low
ketamine 2 8.24 Low Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diphtheria 12 100.00 Very High Very High Very High
Abdominal Pain 4 96.30 Very High Very High Very High
Heart Disease 1 94.36 High High
Cv General 3 Under Development 1 80.64 Quite High
Depression 1 78.80 Quite High
Death 4 73.04 Quite High
Immunization 71 40.96 Quite Low
Stress 1 25.00 Low Low
Erythema 1 6.56 Low Low
Vibrio Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated whether a decreased DTS is associated with increased mortality in a prospective cohort of 5,636 asymptomatic women.
Spec (whether) Negative_regulation (decreased) of DTS
1) Confidence 0.36 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 16054460 Disease Relevance 0.49 Pain Relevance 0.12
Also to evaluate the impact of providing doctors with an AAP DT on patient outcomes, clinical decisions and actions, what factors are likely to determine the usage rates and usability of a DT and the associated costs and likely cost-effectiveness of these DTs in routine use in the UK.
Negative_regulation (effectiveness) of DTs associated with abdominal pain
2) Confidence 0.31 Published 2006 Journal Health Technol Assess Section Abstract Doc Link 17083855 Disease Relevance 0.34 Pain Relevance 0.34
However, depletion of beta-arrestins almost totally blocked both internalization and AC desensitization of DTS.
Negative_regulation (desensitization) of DTS
3) Confidence 0.21 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17565992 Disease Relevance 0 Pain Relevance 0.52
We demonstrated that the DOR agonist D-[Pen(2),Pen(5)]enkephalin could induce receptor internalization and adenylyl cyclase (AC) desensitization of DTS, but with comparatively slower kinetics than those observed with wild type DOR.
Negative_regulation (desensitization) of DTS associated with agonist, enkephalin and opioid receptor
4) Confidence 0.21 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17565992 Disease Relevance 0 Pain Relevance 0.48
These antibodies were evaluated using Vero cell test, the WHO standard method to assess the success of diphtheria vaccination, which relies on the inhibition of a cytotoxic dose of diphtheria toxin (26).
Negative_regulation (inhibition) of diphtheria toxin associated with diphtheria
5) Confidence 0.05 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.37 Pain Relevance 0

General Comments

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