INT12915

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 18
Total Number 24
Disease Relevance 7.53
Pain Relevance 4.15

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cell differentiation (MGP) extracellular space (MGP) extracellular region (MGP)
endoplasmic reticulum (MGP) proteinaceous extracellular matrix (MGP) protein complex (MGP)
Anatomy Link Frequency
cartilage 4
tail 1
lung 1
heart 1
kidney 1
MGP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 315 99.84 Very High Very High Very High
opioid receptor 4 98.92 Very High Very High Very High
antagonist 7 98.28 Very High Very High Very High
tail-flick 4 98.20 Very High Very High Very High
Delta opioid receptors 6 94.56 High High
Opioid 6 94.16 High High
intrathecal 2 93.72 High High
Enkephalin 12 92.44 High High
Antinociceptive 3 92.32 High High
Arthritis 3 91.12 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 323 99.84 Very High Very High Very High
Calcification 291 99.28 Very High Very High Very High
Osteogenic Sarcomas 15 97.96 Very High Very High Very High
Toxicity 72 96.32 Very High Very High Very High
Iron Overload 6 93.88 High High
Sprains And Strains 104 92.16 High High
Cadaver 10 91.76 High High
Arthritis 3 91.12 High High
Temporomandibular Joint Disorders 2 90.92 High High
Adhesions 43 86.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MGP was first isolated from the matrix of bone, but is now known to be synthesized in all tissues tested, with the highest levels of synthesis in heart, kidney, lung, and cartilage (Luo et al. 1997; Price et al. 2000).
Gene_expression (synthesized) of MGP in heart
1) Confidence 0.75 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736540 Disease Relevance 0 Pain Relevance 0
In our analysis of T-138C MGP polymorphism among worker individuals with TT/CT genotypes showed higher BLL (above 70 ?
Gene_expression (polymorphism) of MGP
2) Confidence 0.65 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736540 Disease Relevance 0.51 Pain Relevance 0
The MGP TT/CT individuals (n = 82) showed a hemoglobin of 11.2–14.0 gms/dL and a BLL of 2 ?
Gene_expression (showed) of MGP
3) Confidence 0.57 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736540 Disease Relevance 0.26 Pain Relevance 0
The 3-unsubstituted and substituted analogs of naltrindole (NTI) were synthesized using palladium-catalyzed transformations, and their binding affinity to opioid receptors was determined.
Gene_expression (synthesized) of NTI associated with opioid receptor
4) Confidence 0.51 Published 1998 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 9871544 Disease Relevance 0 Pain Relevance 0.08
Two splint designs were produced: an ordinary stabilization (Michigan type) and a NTI (Nociceptiv trigeminal inhibition).
Gene_expression (produced) of NTI
5) Confidence 0.51 Published 2005 Journal Acta Odontol. Scand. Section Body Doc Link 16040444 Disease Relevance 0.09 Pain Relevance 0
In the absence of NTI, the ED50 values and 95% CL of DPDPE in the tail-flick and hot-plate tests were 2.8 (1.1-4.7) and 19.5 (13.3-33.7) micrograms, respectively.
Neg (absence) Gene_expression (absence) of NTI in tail associated with tail-flick
6) Confidence 0.39 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1658309 Disease Relevance 0 Pain Relevance 1.14
MGP was first isolated from the matrix of bone, but is now known to be synthesized in all tissues tested, with the highest levels of synthesis in heart, kidney, lung, and cartilage (Luo et al. 1997; Price et al. 2000).
Gene_expression (synthesized) of MGP in lung
7) Confidence 0.25 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736540 Disease Relevance 0 Pain Relevance 0
MGP was first isolated from the matrix of bone, but is now known to be synthesized in all tissues tested, with the highest levels of synthesis in heart, kidney, lung, and cartilage (Luo et al. 1997; Price et al. 2000).
Gene_expression (synthesized) of MGP in kidney
8) Confidence 0.25 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736540 Disease Relevance 0 Pain Relevance 0
MGP was first isolated from the matrix of bone, but is now known to be synthesized in all tissues tested, with the highest levels of synthesis in heart, kidney, lung, and cartilage (Luo et al. 1997; Price et al. 2000).
Gene_expression (synthesized) of MGP in cartilage
9) Confidence 0.25 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736540 Disease Relevance 0 Pain Relevance 0
Specifically, microarray-based real-time PCR analysis showed that expression of the following genes decreased during normal culture but increased after mechanical stimulation: MGP (matrix Gla-protein, 3.8-fold), GADD45A (growth arrest and DNA damage-inducible gene, 2.3-fold), UNC5B (unc-5 homolog B, 1.6-fold), TGFB1 (transforming growth factor-?
Gene_expression (expression) of MGP
10) Confidence 0.21 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.35 Pain Relevance 0
Specifically, microarray-based real-time PCR analysis showed that expression of the following genes decreased during normal culture but increased after mechanical stimulation: MGP (matrix Gla-protein, 3.8-fold), GADD45A (growth arrest and DNA damage-inducible gene, 2.3-fold), UNC5B (unc-5 homolog B, 1.6-fold), TGFB1 (transforming growth factor-?
Gene_expression (expression) of matrix Gla-protein
11) Confidence 0.21 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.35 Pain Relevance 0
In the present study, we examined calcium deposition in OA menisci and investigated the expression of several genes implicated in the biomineralization biological process, including ENPP1, ANKH and matrix Gla protein.
Spec (investigated) Gene_expression (expression) of matrix Gla protein associated with calcification and osteoarthritis
12) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.97 Pain Relevance 0.47
In addition, microarray and real-time RT-PCR analyses indicated that the expression of matrix Gla protein and serglycin, which are putative endogenous calcification inhibitors [42,43], was also upregulated in OA meniscal cells.


Gene_expression (expression) of matrix Gla protein associated with calcification and osteoarthritis
13) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.41 Pain Relevance 0.34
Specifically, microarray-based real-time PCR analysis showed that expression of the following genes decreased during normal culture but increased after mechanical stimulation: MGP (matrix Gla-protein, 3.8-fold), GADD45A (growth arrest and DNA damage-inducible gene, 2.3-fold), UNC5B (unc-5 homolog B, 1.6-fold), TGFB1 (transforming growth factor-?
Gene_expression (expression) of matrix Gla-protein
14) Confidence 0.19 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.35 Pain Relevance 0
Specifically, microarray-based real-time PCR analysis showed that expression of the following genes decreased during normal culture but increased after mechanical stimulation: MGP (matrix Gla-protein, 3.8-fold), GADD45A (growth arrest and DNA damage-inducible gene, 2.3-fold), UNC5B (unc-5 homolog B, 1.6-fold), TGFB1 (transforming growth factor-?
Gene_expression (transforming) of MGP
15) Confidence 0.19 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2939640 Disease Relevance 0.40 Pain Relevance 0
With the exception of KRT18, KRT19 and PTN, the genes identified in rat studies (GPC3, ANXA3, VIM, COMP and MGP) and canine studies (A2M, ANXA4, DSC2, NCAM1) did not show a substantial differential expression in bovine NP cells compared with AC&AF cells.
Gene_expression (expression) of MGP
16) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Naltrindole (NTI) and naltriben (NTB), a benzofuran derivative of NTI, were recently synthesized as highly selective delta-opioid receptor antagonists.
Gene_expression (synthesized) of NTI associated with antagonist and opioid receptor
17) Confidence 0.15 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870983 Disease Relevance 0 Pain Relevance 0.75
The activities and protein levels of ENPP1, ANKH and matrix Gla protein in OA meniscal cells were not obtained in the present work.
Gene_expression (levels) of matrix Gla protein associated with osteoarthritis
18) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888206 Disease Relevance 1.55 Pain Relevance 0.46
Expression of matrix Gla protein (MGP)
Gene_expression (Expression) of matrix Gla protein
19) Confidence 0.14 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2018722 Disease Relevance 0 Pain Relevance 0
To answer these questions, notochordal cells were isolated from dogs, cultured on different PPE:N surfaces, and the expression of vimentin (VIM), pleiotrophin heparin binding factor (PTN), matrix gla protein (MGP), cartilage oligomeric matrix protein (COMP), and keratin (KRT) genes analyzed.
Spec (analyzed) Gene_expression (expression) of matrix gla protein in cartilage
20) Confidence 0.12 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC2018722 Disease Relevance 0.06 Pain Relevance 0

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