INT129153

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN1B) endosome (CDKN1B) nucleoplasm (CDKN1B)
nucleus (CDKN1B) cell cycle (CDKN1B) kinase activity (CDKN1B)
CDKN1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 91.24 High High
cytokine 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 3 99.82 Very High Very High Very High
Alzheimer's Dementia 5 94.88 High High
Apoptosis 22 88.52 High High
Leukemia 3 84.00 Quite High
Disease 7 75.00 Quite High
Myeloid Leukemia 25 69.40 Quite High
INFLAMMATION 2 54.36 Quite High
Epilepsy 1 54.32 Quite High
Myeloproliferative Disorder 45 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cyclopentenone induced a partial inhibition of retinoblastoma protein phosphorylation and increased levels of the CDK inhibitor p27kip1.
Phosphorylation (phosphorylation) of p27kip1 associated with retinoblastoma
1) Confidence 0.61 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16061222 Disease Relevance 0.75 Pain Relevance 0.33
Their anti-proliferative effect is mediated through increased production of cell cycle inhibitor proteins p21CIP1 [64–68, 72, 73, 77, 78] and in some instances, p27KIP1 [64, 67, 68], attenuation of cyclin D1 [73, 78] and hypophosphorylation of the retinoblastoma (Rb) protein [45].
Phosphorylation (hypophosphorylation) of p27KIP1 associated with retinoblastoma
2) Confidence 0.12 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.66 Pain Relevance 0

General Comments

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