INT129154

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.02
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 1.61
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
peripheral nervous system 1
Pirt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 33 100.00 Very High Very High Very High
Peripheral nervous system 4 99.20 Very High Very High Very High
Pain 22 97.68 Very High Very High Very High
Potency 1 97.32 Very High Very High Very High
tissue acidosis 4 97.08 Very High Very High Very High
addiction 4 93.96 High High
Nav1.2 42 91.84 High High
aPETx2 3 91.36 High High
Inflammatory mediators 2 86.16 High High
Catecholamine 9 82.56 Quite High
Disease Link Frequency Relevance Heat
Pain 15 97.68 Very High Very High Very High
Acidosis 4 96.80 Very High Very High Very High
Disease 2 96.32 Very High Very High Very High
Nociception 1 95.28 Very High Very High Very High
INFLAMMATION 9 86.16 High High
Ganglion Cysts 9 74.32 Quite High
Hyperalgesia 2 38.72 Quite Low
Natriuresis 2 25.00 Low Low
Stress 2 25.00 Low Low
Diuresis 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acid-sensing ion channels (ASICs) are activated by a decrease in extracellular pH.
Positive_regulation (activated) of channels associated with asic
1) Confidence 0.02 Published 2007 Journal Neuroscience Section Abstract Doc Link 17258862 Disease Relevance 0.33 Pain Relevance 0.30
Acid Sensing Ion Channels (ASICs) are a group of sodium-selective ion channels that are activated by low extracellular pH.
Positive_regulation (activated) of channels associated with asic
2) Confidence 0.01 Published 2005 Journal Pain Section Abstract Doc Link 16061325 Disease Relevance 0.24 Pain Relevance 0.28
Acid Sensing Ion Channels (ASICs) are a group of sodium-selective ion channels that are activated by low extracellular pH.
Positive_regulation (activated) of Channels associated with asic
3) Confidence 0.01 Published 2005 Journal Pain Section Abstract Doc Link 16061325 Disease Relevance 0.24 Pain Relevance 0.28
Acid-sensing ion channels (ASICs) are a class of ion channels activated by extracellular protons and are believed to mediate the pain caused by tissue acidosis.
Positive_regulation (activated) of channels associated with pain, acidosis, tissue acidosis and asic
4) Confidence 0.01 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18045919 Disease Relevance 0.35 Pain Relevance 0.42
Acid-sensing ion channels (ASICs) are a class of ion channels activated by extracellular protons and are believed to mediate the pain caused by tissue acidosis.
Positive_regulation (activated) of channels associated with pain, acidosis, tissue acidosis and asic
5) Confidence 0.01 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18045919 Disease Relevance 0.35 Pain Relevance 0.42
These potentials are too negative to account for the activation of rat aortic-SMC L-type Ca2+ channels that have a threshold of activation above ?
Positive_regulation (activation) of channels
6) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.34
Nav channels were distributed in the membranes, as expected for voltage-gated proteins, and in the cytoplasm of the rat aortic SMCs.
Positive_regulation (distributed) of channels
7) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.34
We also reasoned that the use of massive concentrations of KCl, resulting in large depolarizations, could directly activate Ca2+ channels.
Positive_regulation (activate) of channels
8) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.10
Our results suggest that ApC slows the conformational changes required for fast inactivation of the mammalian Na+ channels in a form similar to other site-3 toxins, although with a greater potency than ATX-II, a highly homologous anemone toxin.
Positive_regulation (inactivation) of channels associated with potency
9) Confidence 0.00 Published 2006 Journal Brain Res. Section Abstract Doc Link 16914123 Disease Relevance 0 Pain Relevance 0.28
Acid sensing ion channels (ASICs) are pH-sensitive channels that are distributed in the central and peripheral nervous system and which are believed to play a key role in pain perception.
Positive_regulation (distributed) of channels in peripheral nervous system associated with pain, peripheral nervous system and asic
10) Confidence 0.00 Published 2009 Journal Toxicon Section Abstract Doc Link 19306891 Disease Relevance 0.10 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox