INT129155

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.36
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
neurons 1
masseter 1
oocytes 1
Accn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 29 100.00 Very High Very High Very High
Inflammation 9 98.44 Very High Very High Very High
dorsal root ganglion 3 97.88 Very High Very High Very High
aPETx2 3 95.28 Very High Very High Very High
Pain 16 86.60 High High
Peripheral nervous system 1 84.60 Quite High
trigeminal ganglion 24 76.40 Quite High
qutenza 17 73.08 Quite High
c fibre 4 72.72 Quite High
Thermal hyperalgesia 1 72.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 98.44 Very High Very High Very High
Ganglion Cysts 40 97.88 Very High Very High Very High
Disease 2 86.64 High High
Pain 8 86.60 High High
Hyperalgesia 3 72.56 Quite High
Nociception 25 70.76 Quite High
Diuresis 1 52.96 Quite High
Natriuresis 1 52.00 Quite High
Targeted Disruption 4 29.28 Quite Low
Cough 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The folded synthetic toxin had an IC(50) of 57 nM for inhibition of rat ASIC3 channels expressed in Xenopus oocytes, in agreement with the IC(50) reported for the native toxin (63 nM).
Negative_regulation (inhibition) of ASIC3 in oocytes
1) Confidence 0.46 Published 2009 Journal Toxicon Section Abstract Doc Link 19306891 Disease Relevance 0.09 Pain Relevance 0.43
A-317567 produced concentration-dependent inhibition of all pH 4.5-evoked ASIC currents with an IC50 ranging between 2 and 30muM, depending upon the type of ASIC current activated.
Negative_regulation (inhibition) of ASIC associated with asic
2) Confidence 0.37 Published 2005 Journal Pain Section Abstract Doc Link 16061325 Disease Relevance 0.67 Pain Relevance 0.53
These relative proportions might be a slight overestimation of the situation under physiological conditions, since tracer application caused, to some extent, local inflammation, and inflammatory conditions lead to increased ASIC3 transcription in vivo and to an increased number of ASIC3 expressing neurons in vitro [46,47].
Negative_regulation (number) of ASIC3 in neurons associated with inflammation
3) Confidence 0.37 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.42 Pain Relevance 0.43
The ASIC channels in trigeminal masseter afferents seemed to be largely comprised of homomeric ASIC3 channels or ASIC channel heteromers containing ASIC3.
Negative_regulation (comprised) of ASIC3 in masseter associated with asic
4) Confidence 0.24 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.18 Pain Relevance 0.68

General Comments

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