INT129161

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.32
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
neurons 1
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 15 100.00 Very High Very High Very High
qutenza 10 100.00 Very High Very High Very High
Serotonin 9 100.00 Very High Very High Very High
vanilloid receptor subtype 1 1 100.00 Very High Very High Very High
Inflammation 20 99.76 Very High Very High Very High
Pain 55 97.04 Very High Very High Very High
cytokine 3 96.08 Very High Very High Very High
nociceptor 6 95.20 Very High Very High Very High
trigeminal ganglion 1 91.80 High High
calcitonin gene related peptide 4 90.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 18 99.76 Very High Very High Very High
Benign Prostatic Hypertrophy 2 98.80 Very High Very High Very High
Nociception 14 98.64 Very High Very High Very High
Pain 45 93.60 High High
Ganglion Cysts 2 91.80 High High
Labor Pain 9 87.68 High High
Repression 1 50.48 Quite High
Bladder Disease 35 50.00 Quite Low
Myoma 1 8.40 Low Low
Overactive Bladder 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPM8 is not the only thermosensitive element in cold receptors and interacts with other ionic currents to shape cold receptor activity.
TRPM8 Binding (interacts) of
1) Confidence 0.48 Published 2005 Journal Pflugers Arch. Section Abstract Doc Link 16075243 Disease Relevance 0.24 Pain Relevance 0.27
They further characterized the TRPM8-positive neurons by double staining analysis with anti-NF200, a marker of A delta fibres, and anti-TRPM8 antibodies.
TRPM8 Binding (characterized) of in neurons
2) Confidence 0.37 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.09 Pain Relevance 0.35
In addition to TRPM8, a cool receptor, TRPA1 is recently recognized as a cold receptor.
TRPM8 Binding (recognized) of
3) Confidence 0.34 Published 2008 Journal Urology Section Abstract Doc Link 18384850 Disease Relevance 0.20 Pain Relevance 0.10
Accumulating evidence suggests a significant interaction between serotonin and one of the transient receptor potential ion channels, the capsaicin-sensitive transient receptor potential vanilloid type 1.
transient receptor potential Binding (interaction) of associated with qutenza and serotonin
4) Confidence 0.31 Published 2008 Journal Acta Physiol (Oxf) Section Abstract Doc Link 18462271 Disease Relevance 0 Pain Relevance 0.46
Chemical ligands are known to interact within the transmembrane domains 2 to 4 region for the other well studied TRP channels such as TRPV1 [23-25], TRPM8 [26]and TRPV4 [27], but critical residues for heat activation are still unknown.
TRPM8 Binding (interact) of associated with trp channel
5) Confidence 0.15 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222611 Disease Relevance 0 Pain Relevance 0.38
The transient receptor potential vanilloid receptor subtype 1 (TRPV1, previously known as VR1) is also a biomolecule associated with inflammatory conditions and nociception.
transient receptor potential Binding (associated) of associated with nociception, vanilloid receptor subtype 1 and inflammation
6) Confidence 0.09 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254422 Disease Relevance 0.74 Pain Relevance 0.90
Interestingly, in TRPM8 channels, binding of phosphatidylinositol bisphosphate (PIP2) leads to channel activation

[73].

TRPM8 Binding (binding) of
7) Confidence 0.06 Published 2008 Journal Journal of Biophysics Section Body Doc Link PMC2814129 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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