INT129179

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.47
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ank1) plasma membrane (Ank1) cytoskeleton (Ank1)
nucleus (Ank1) cytoplasm (Ank1)
Anatomy Link Frequency
sensory neurons 1
neurons 1
nodes 1
olfactory epithelium 1
Ank1 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 13 100.00 Very High Very High Very High
sodium channel 6 99.96 Very High Very High Very High
Pain 5 98.92 Very High Very High Very High
Nav1.6 6 97.72 Very High Very High Very High
Nav1.2 2 97.50 Very High Very High Very High
agonist 1 75.00 Quite High
Action potential 1 49.40 Quite Low
fifth nerve 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 1 99.92 Very High Very High Very High
Pain 4 98.92 Very High Very High Very High
Disease 2 75.00 Quite High
Loss Of Sense Of Smell 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Brain Injury 2 5.00 Very Low Very Low Very Low
Overactive Bladder 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that transient receptor potential ankyrin 1 (TRPA1), expressed by sensory neurons in the pain pathway, is a receptor for H(2)O(2).
Gene_expression (expressed) of ankyrin 1 in sensory neurons associated with pain
1) Confidence 0.31 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18364033 Disease Relevance 0.29 Pain Relevance 0.34
The transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1), which are expressed in the nociceptive neurons, induce a sensation of heat on activation by some pungent ingredients in food.
Gene_expression (expressed) of ankyrin 1 in neurons associated with nociception
2) Confidence 0.11 Published 2009 Journal Life Sci. Section Abstract Doc Link 19409911 Disease Relevance 0.10 Pain Relevance 0.04
Using specific antibodies against the Nav1.2 and Nav1.6 sodium channels, ankyrin G and Caspr 1, and a pan sodium channel antibody, we found that a similar proportion of ankyrin G-positive nodes of Ranvier express sodium channels in mutant and wild-type animals and that nodal expression of Nav1.2 persists in med mice.
Gene_expression (express) of ankyrin in nodes associated with sodium channel, nav1.2 and nav1.6
3) Confidence 0.07 Published 2006 Journal Glia Section Abstract Doc Link 16078241 Disease Relevance 0.07 Pain Relevance 0.92
Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium

Conclusion: It is suggested that TRPV1, 2, 3, and 4, TRPM5 and 8, and TRPA1 may play several roles in the olfactory epithelium (OE), contributing to olfactory chemosensation, olfactory adaptation, olfactory-trigeminal interaction, and OE fluid homeostasis.

Gene_expression (Expression) of ankyrin in olfactory epithelium associated with trp channel
4) Confidence 0.02 Published 2010 Journal Acta Oto-Laryngologica Section Title Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.05

General Comments

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