INT129189

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 13
Disease Relevance 16.51
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
Anatomy Link Frequency
colon 8
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 12 92.24 High High
cINOD 25 81.68 Quite High
COX-2 inhibitor 24 75.40 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 613 99.96 Very High Very High Very High
Cancer 948 99.84 Very High Very High Very High
Metastasis 168 99.32 Very High Very High Very High
Carcinoma 60 94.28 High High
Shock 96 91.04 High High
Breast Cancer 36 90.72 High High
Apoptosis 73 86.72 High High
Malignant Neoplastic Disease 48 84.80 Quite High
Stress 60 83.80 Quite High
INFLAMMATION 25 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac sulfide and troglitazone regulated ATF3 promoter activity, which was suppressed when the two Egr-1 sites were mutated.
Negative_regulation (suppressed) of ATF3
1) Confidence 0.58 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.18 Pain Relevance 0.06
Furthermore, this study is the first to demonstrate that loss of ATF3 via shRNA-mediated down-regulation increases the migration properties of HCT116 colon cancer cells in vitro and promotes tumor growth and metastasis in vivo.
Negative_regulation (loss) of ATF3 in colon associated with cancer, colon cancer and metastasis
2) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.51 Pain Relevance 0
However, this group was not able to validate in an in vivo setting that loss of ATF3 function is conversely associated with increased growth rates and metastasis, hence our study further expands the knowledge on ATF3 function beyond these aspects.
Negative_regulation (loss) of ATF3 associated with metastasis
3) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.98 Pain Relevance 0.12
We observed an enhanced migration behavior after ATF3 inhibition in vitro and hypothesized that loss of ATF3 function may also lead to an increased tumor metastasis in vivo, an aspect that has not been comprehensively investigated to date.
Negative_regulation (loss) of ATF3 associated with metastasis
4) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.18 Pain Relevance 0.10
Impact of ATF3 down-regulation on tumor growth in vivo
Negative_regulation (regulation) of ATF3 associated with cancer
5) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.10 Pain Relevance 0
We conclude that ATF3 is likely to be down-regulated in colon cancers, hence supporting the rationale of therapeutically inducing ATF3 expression in this cancer entity.


Negative_regulation (down) of ATF3 in colon associated with cancer and colon cancer
6) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.62 Pain Relevance 0
In conclusion, the present study shows that down-regulation of ATF3 enhances both invasive properties and tumor metastasis of HCT116 colon cancer cells in vivo.
Negative_regulation (regulation) of ATF3 in colon associated with colon cancer and metastasis
7) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.11 Pain Relevance 0
Importantly, down-regulation of ATF3 markedly increased the migration ability of colon cancer cells in vitro (Figure 3C).
Negative_regulation (regulation) of ATF3 in colon associated with colon cancer
8) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.03 Pain Relevance 0
Impact of ATF3 down-regulation on colon cancer metastasis in vivo
Negative_regulation (regulation) of ATF3 in colon associated with colon cancer and metastasis
9) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.41 Pain Relevance 0
The impact of ATF3 down-regulation on cancer growth and metastasis were investigated in a subcutaneous tumor model, a model of hepatic tumor growth and in a model of peritoneal carcinomatosis.
Negative_regulation (regulation) of ATF3 associated with cancer, carcinoma and metastasis
10) Confidence 0.43 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC3003660 Disease Relevance 1.76 Pain Relevance 0.05
In contrast, we could show that in HCT116 colon cancer, loss of ATF3 function does result in a higher pro-migration capacity in vitro and an accelerated tumor growth with increased metastasis in vivo.
Negative_regulation (loss) of ATF3 in colon associated with cancer, colon cancer and metastasis
11) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.97 Pain Relevance 0
This important result will be further addressed in future experiments, where loss of ATF3 function as well as ATF3-overexpression will be investigated in colon cancer cells with different genetic background.
Negative_regulation (loss) of ATF3-overexpression in colon associated with colon cancer
12) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.34 Pain Relevance 0
This important result will be further addressed in future experiments, where loss of ATF3 function as well as ATF3-overexpression will be investigated in colon cancer cells with different genetic background.
Negative_regulation (loss) of ATF3 in colon associated with colon cancer
13) Confidence 0.42 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.32 Pain Relevance 0

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