INT129190

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.96
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 61.88 Quite High
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 54 94.64 High High
Cancer 79 91.56 High High
Apoptosis 9 68.52 Quite High
INFLAMMATION 5 61.64 Quite High
Shock 8 50.00 Quite Low
Pressure And Volume Under Development 2 30.12 Quite Low
Carcinoma 5 20.40 Low Low
Metastasis 14 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The biological effects of Hsp90 inhibitor-mediated induction of ATF3 are currently not known.
Negative_regulation (inhibitor) of Positive_regulation (induction) of ATF3
1) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.71 Pain Relevance 0
These compounds induced phosphorylation of extracellular signal-regulated kinase1/2 (Erk1/2), whereas a dominant-negative inhibitor of mitogen-activate protein kinase kinase (MEK) 1 blocked the induction of ATF3.
Negative_regulation (blocked) of Positive_regulation (induction) of ATF3
2) Confidence 0.43 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.05 Pain Relevance 0
The MEK1/2 inhibitor PD98059 (2'-amino-3'-methoxyflavone) blocked the induction of ATF3 and Egr-1 mRNA expression and ATF3 promoter activity by these compounds.
Negative_regulation (blocked) of Positive_regulation (induction) of ATF3
3) Confidence 0.43 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0 Pain Relevance 0
ATF3 and Egr-1 mRNA and protein and ATF3 promoter activity were induced by these compounds, whereas induction of ATF3 by these compounds was blocked by Egr-1 small interfering RNA.
Negative_regulation (blocked) of Positive_regulation (induction) of ATF3
4) Confidence 0.43 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.19 Pain Relevance 0.06

General Comments

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