INT129191

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 17
Disease Relevance 17.04
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
Anatomy Link Frequency
colon 6
nerve 2
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 18 98.48 Very High Very High Very High
cINOD 48 98.14 Very High Very High Very High
Morphine 8 97.56 Very High Very High Very High
Endep 2 97.16 Very High Very High Very High
COX-2 inhibitor 26 97.12 Very High Very High Very High
Gabapentin 4 96.44 Very High Very High Very High
antagonist 38 96.20 Very High Very High Very High
Hyperalgesia 20 90.76 High High
allodynia 16 88.56 High High
Inflammation 68 82.56 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 515 99.86 Very High Very High Very High
Nervous System Injury 26 99.70 Very High Very High Very High
Cancer 810 99.36 Very High Very High Very High
Breast Cancer 30 98.84 Very High Very High Very High
Lung Cancer 59 98.52 Very High Very High Very High
Ganglion Cysts 18 98.48 Very High Very High Very High
Metastasis 140 98.28 Very High Very High Very High
Stress 53 97.90 Very High Very High Very High
Shock 82 97.20 Very High Very High Very High
Apoptosis 85 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the regulation of ATF3 by anticancer agents is not known.
Regulation (regulation) of ATF3
1) Confidence 0.61 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.28 Pain Relevance 0.09
We identified three putative Egr-1 binding sites in the promoter of ATF3 and report for the first time that the molecular mechanism responsible for the transcriptional regulation of ATF3 by two divergent pharmaceutical compounds, sulindac sulfide and troglitazone, involved the early growth response gene-1 (Egr-1).
Regulation (regulation) of ATF3
2) Confidence 0.61 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.24 Pain Relevance 0.08
Sulindac sulfide and troglitazone regulated ATF3 promoter activity, which was suppressed when the two Egr-1 sites were mutated.
Regulation (regulated) of ATF3
3) Confidence 0.61 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.18 Pain Relevance 0.06
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
Regulation (regulation) of activating transcription factor 3
4) Confidence 0.61 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16079301 Disease Relevance 0.27 Pain Relevance 0.09
To further validate these results, we investigated whether blocking Hsp90 also leads to ATF3 up-regulation in other human cancer cell types.
Spec (whether) Regulation (regulation) of ATF3 associated with cancer
5) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.62 Pain Relevance 0
Importantly, down-regulation of ATF3 markedly increased the migration ability of colon cancer cells in vitro (Figure 3C).
Regulation (regulation) of ATF3 in colon associated with colon cancer
6) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.03 Pain Relevance 0
In colon cancer, down-regulating ATF3 in HT29 colon cancer cells with antisense oligonucleotides apparently diminished entopic tumor growth and metastasis in mice [19].
Regulation (regulating) of ATF3 in colon associated with cancer, colon cancer and metastasis
7) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.94 Pain Relevance 0
One clinical significance of our findings is that treatment-induced up-regulation of ATF3, as for example via Hsp90-inhibition or COX-2 inhibition, may be beneficial in some tumors for reducing growth and metastasis [8,14].
Regulation (regulation) of ATF3 associated with cancer and metastasis
8) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.08 Pain Relevance 0.12
In subsequent hepatic and peritoneal tumor models, we were able to demonstrate a significant increase in tumor burden, cancer dissemination, and tumorigenicity upon further down-regulating ATF3.
Regulation (regulating) of ATF3 associated with cancer
9) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.27 Pain Relevance 0.08
This is consistent with MAPK regulation of ATF3 [36] as well as the GADD genes [44,45].
Regulation (regulation) of ATF3
10) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 1.16 Pain Relevance 0
In view of the fact that ATF3 is stress-inducible and continuously detectable in colon cancer cells, we used an shRNA approach for specifically targeting ATF3 in HCT116 colon cancer cells, with the intention to determine the biological effects of a further ATF3 down-regulation in this cancer entity.
Regulation (targeting) of ATF3 in colon associated with stress, cancer and colon cancer
11) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.93 Pain Relevance 0
In conclusion, ATF3 down-regulation in colon cancer promotes tumor growth and metastasis.
Regulation (regulation) of ATF3 in colon associated with cancer, colon cancer and metastasis
12) Confidence 0.27 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC3003660 Disease Relevance 2.06 Pain Relevance 0.03
Together, these in vitro experiments indicate that ATF3 down-regulation harbors the potential to increase the metastatic potential of colon cancer cells.


Regulation (regulation) of ATF3 in colon associated with colon cancer
13) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.05 Pain Relevance 0
In the present study, we sought to clarify ATF3 regulation and its role in human colon cancer using xenogenic mouse models.
Regulation (regulation) of ATF3 in colon associated with colon cancer
14) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.56 Pain Relevance 0.14
Regulation of ATF3 was determined in cancer cells using signaling inhibitors and a heat-shock protein-90 (Hsp90) antagonist.
Regulation (Regulation) of ATF3 associated with cancer, antagonist and shock
15) Confidence 0.27 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC3003660 Disease Relevance 1.29 Pain Relevance 0.05
Further characterization shows that, in the early stages, there is sensitivity to NSAIDs [173,174] whereas later stages appear to demonstrate evidence of nerve damage with elevated activating transcription factor-3 (ATF-3) immunoreactivity in innervating cell bodies of lumber-DRG and sensitivity to morphine, amitriptyline and gabapentin [173,176].
Regulation (immunoreactivity) of activating transcription factor-3 in nerve associated with dorsal root ganglion, nervous system injury, cinod, gabapentin, endep and morphine
16) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.08 Pain Relevance 0.93
Further characterization shows that, in the early stages, there is sensitivity to NSAIDs [173,174] whereas later stages appear to demonstrate evidence of nerve damage with elevated activating transcription factor-3 (ATF-3) immunoreactivity in innervating cell bodies of lumber-DRG and sensitivity to morphine, amitriptyline and gabapentin [173,176].
Regulation (immunoreactivity) of ATF-3 in nerve associated with dorsal root ganglion, nervous system injury, cinod, gabapentin, endep and morphine
17) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.01 Pain Relevance 0.87

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