INT129192

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.81
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 94.32 High High
Inflammation 141 85.52 High High
cytokine 30 81.20 Quite High
agonist 24 60.60 Quite High
chemokine 10 35.12 Quite Low
Inflammatory response 11 29.04 Quite Low
addiction 1 13.04 Low Low
adenocard 32 5.00 Very Low Very Low Very Low
Nicotine 9 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 158 93.60 High High
Colon Cancer 3 91.04 High High
Apoptosis 13 86.60 High High
Stress 69 61.12 Quite High
Malignant Neoplastic Disease 20 50.00 Quite Low
Cancer 48 5.00 Very Low Very Low Very Low
Lung Cancer 47 5.00 Very Low Very Low Very Low
Nicotine Addiction 30 5.00 Very Low Very Low Very Low
Hypoxia 12 5.00 Very Low Very Low Very Low
Carcinoma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, overexpression of Egr-1 protein induced ATF3 mRNA 3.5-fold and transcriptional activity of an ATF3 promoter construct more than 20-fold.
Transcription (activity) of ATF3
1) Confidence 0.53 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.21 Pain Relevance 0.07
For example, overexpression of Egr-1 protein induced ATF3 mRNA 3.5-fold and transcriptional activity of an ATF3 promoter construct more than 20-fold.
Transcription (activity) of ATF3
2) Confidence 0.53 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.22 Pain Relevance 0.07
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
Transcription (Transcriptional) of activating transcription factor 3
3) Confidence 0.53 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16079301 Disease Relevance 0.27 Pain Relevance 0.09
A2AR engagement, PGE2 or cAMP-elevating agents each increased mRNA expression of immunomodulatory transcription factors NR4A3, ATF3, TNFAIP3 and IER2, of the enzyme COX-2, of dual-specificity phosphatases 1 and 2 and of the regulatory element SOCS3.
Transcription (expression) of ATF3
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.49 Pain Relevance 0.32
A2AR engagement, PGE2 or cAMP-elevating agents each increased mRNA expression of immunomodulatory transcription factors NR4A3, ATF3, TNFAIP3 and IER2, of the enzyme COX-2, of dual-specificity phosphatases 1 and 2 and of the regulatory element SOCS3.
Transcription (transcription) of ATF3
5) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2654409 Disease Relevance 0.49 Pain Relevance 0.31
Consistent with this protein data, the array profiles of cigarette smoke signature genes shown in Additional file 1 – Supplemental Table S1 shows that the mRNA transcripts for CHOP (also denoted DDIT3), ATF3, and GADD34 (also denoted PPPIR15A) are upregulated by CS treatment.


Transcription (transcripts) of ATF3
6) Confidence 0.33 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.13 Pain Relevance 0

General Comments

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