INT129193

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.82
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 99.12 Very High Very High Very High
Colon Cancer 3 96.56 Very High Very High Very High
Apoptosis 3 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, our laboratory identified activating transcription factor 3 (ATF3) as up-regulated by nonsteroidal anti-inflammatory drugs using microarray analysis of mRNA from human colorectal cancer cells treated with sulindac sulfide.
Positive_regulation (up-regulated) of Positive_regulation (activating) of ATF3 associated with inflammation, colon cancer and cinod
1) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.28 Pain Relevance 0.10
We identified three putative Egr-1 binding sites in the promoter of ATF3 and report for the first time that the molecular mechanism responsible for the transcriptional regulation of ATF3 by two divergent pharmaceutical compounds, sulindac sulfide and troglitazone, involved the early growth response gene-1 (Egr-1).
Positive_regulation (putative) of Positive_regulation (promoter) of ATF3
2) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.26 Pain Relevance 0.08
Previously, our laboratory identified activating transcription factor 3 (ATF3) as up-regulated by nonsteroidal anti-inflammatory drugs using microarray analysis of mRNA from human colorectal cancer cells treated with sulindac sulfide.
Positive_regulation (up-regulated) of Positive_regulation (up-regulated) of activating transcription factor 3 associated with inflammation, colon cancer and cinod
3) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.28 Pain Relevance 0.10

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