INT129207

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 114
Total Number 117
Disease Relevance 68.54
Pain Relevance 30.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
lung 9
liver 8
macrophages 7
neutrophils 5
plasma 4
Cxcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3688 100.00 Very High Very High Very High
cytokine 3183 100.00 Very High Very High Very High
chemokine 1391 100.00 Very High Very High Very High
Paracetamol 19 99.38 Very High Very High Very High
Inflammatory response 750 99.04 Very High Very High Very High
psoriasis 45 98.44 Very High Very High Very High
Inflammatory mediators 134 98.32 Very High Very High Very High
ischemia 464 97.76 Very High Very High Very High
COX-2 inhibitor 71 96.96 Very High Very High Very High
tolerance 116 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4442 100.00 Very High Very High Very High
Herpes Simplex Virus 715 100.00 Very High Very High Very High
Adhesions 518 100.00 Very High Very High Very High
Cancer 268 100.00 Very High Very High Very High
Necrosis 241 100.00 Very High Very High Very High
Injury 2771 99.96 Very High Very High Very High
Infection 1438 99.88 Very High Very High Very High
Disease 522 99.76 Very High Very High Very High
Apoptosis 228 99.50 Very High Very High Very High
Urological Neuroanatomy 84 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, PAG had no effect on LPS-induced production of the hypernociceptive cytokines, TNF-alpha, IL-1beta and CXCL1/KC and on hypernociception induced by PGE(2), a directly acting hypernociceptive mediator.
Gene_expression (production) of CXCL1 associated with urological neuroanatomy and cytokine
1) Confidence 0.75 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18585702 Disease Relevance 0.51 Pain Relevance 0.12
Its proinflammatory potential has been characterized in in vitro airway epithelial cells and fibroblasts where it induced the expression of various cytokines, chemokines, and adhesion molecules such as IL-6, IL-8, GRO?
Gene_expression (expression) of GRO in fibroblasts associated with chemokine, adhesions and cytokine
2) Confidence 0.75 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.52 Pain Relevance 0.17
Multiplex bead immunoassay (Lincoplex) was performed according to the manufacturer's protocol on the Luminex 100 platform to measure concentrations of KC/CXCL1, MCP-1/CCL2, MIP-1?
Gene_expression (/) of CXCL1
3) Confidence 0.65 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.07 Pain Relevance 0.18
Multiplex bead immunoassay (Lincoplex) was performed according to the manufacturer's protocol on the Luminex 100 platform to measure concentrations of KC/CXCL1, MCP-1/CCL2, MIP-1?
Gene_expression (/) of CXCL1
4) Confidence 0.65 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.07 Pain Relevance 0.18
Consistent with the first experiment, there was a significant effect of mechanical ventilation on lung levels of KC/CXCL1, MCP1/CCL2, MIP1?
Gene_expression (/) of CXCL1 in lung
5) Confidence 0.65 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.38 Pain Relevance 0.22
Consistent with the first experiment, there was a significant effect of mechanical ventilation on lung levels of KC/CXCL1, MCP1/CCL2, MIP1?
Gene_expression (levels) of CXCL1 in lung
6) Confidence 0.65 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.38 Pain Relevance 0.22
Consistent with the first experiment, there was a significant effect of mechanical ventilation on lung levels of KC/CXCL1, MCP1/CCL2, MIP1?
Gene_expression (/) of CXCL1 in lung
7) Confidence 0.65 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.38 Pain Relevance 0.22
I/R-induced changes in KC (CXCL1) and MCP-1 (CCL2) protein expression in the mesentery were paralleled by changes in mRNA levels, as detected by real-time PCR.
Gene_expression (expression) of CXCL1 in mesentery
8) Confidence 0.65 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.07 Pain Relevance 0.16
19- and 16-fold increase in KC and MCP-1 gene expression, respectively, over WT I/R tissues (data not shown; n=6; P<0.05).


Gene_expression (expression) of KC
9) Confidence 0.65 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.05 Pain Relevance 0.14
I/R-induced changes in KC (CXCL1) and MCP-1 (CCL2) protein expression in the mesentery were paralleled by changes in mRNA levels, as detected by real-time PCR.
Gene_expression (expression) of KC in mesentery
10) Confidence 0.65 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.07 Pain Relevance 0.16
Whereas MCP-1 and KC could not be detected, soluble CD62L, IL-1, and TNF-?
Neg (not) Gene_expression (detected) of KC
11) Confidence 0.65 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.07 Pain Relevance 0.07
These cellular alterations were complemented by higher expression of mesenteric tissue CCL2 and CXCL1 (mRNA and protein) and myeloperoxydase, as compared with wild-type animals.
Gene_expression (expression) of CXCL1
12) Confidence 0.65 Published 2008 Journal FASEB J Section Abstract Doc Link PMC2700033 Disease Relevance 0.57 Pain Relevance 0.23
Furthermore, expression of CXCR2 mRNA was similarly increased in parallel to the production of both CXCL1 and CXCL2/3 ligands and neutrophil sequestration during dsRNA-induced lung inflammation.
Gene_expression (production) of CXCL1 in lung associated with inflammation and pneumonia
13) Confidence 0.64 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.11 Pain Relevance 0.21
In view of the inhibition of CXCL1 production in the kidney by macrophage depletion and the documented protective effect of CXCL1 inhibition in ischemic AKI [64, 65], it is possible that part of the protective effect of macrophage depletion in ischemic AKI is mediated by inhibition of CXCL1.

6.

Gene_expression (production) of CXCL1 in macrophage associated with injury
14) Confidence 0.64 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.35 Pain Relevance 0.13
A possible mechanism of this protective effect is inhibition of production of CXCL1 by macrophages in ischemic AKI.
Gene_expression (production) of CXCL1 in macrophages associated with injury
15) Confidence 0.64 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.93 Pain Relevance 0.10
Selective antagonism of the C3a receptor significantly attenuated production of MIP-2 and KC, whereas C5a receptor antagonism and prevention of membrane attack complex (MAC) formation did not have a significant effect on MIP-2 and KC production [34].
Gene_expression (production) of KC
16) Confidence 0.64 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.63 Pain Relevance 0.23
Thus, it was determined whether macrophages are the source of CXCL1 in the kidney in ischemic AKI [42].
Gene_expression (source) of CXCL1 in kidney associated with injury
17) Confidence 0.64 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.05 Pain Relevance 0.09
Inhibition of macrophage infiltration in the kidney using liposomal encapsulated clodronate prevented the increase in CXCL1 in the kidney suggesting that macrophages are the main source of CXCL1 in ischemic AKI.
Gene_expression (source) of CXCL1 in macrophages associated with injury
18) Confidence 0.64 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.30 Pain Relevance 0.10
APAP administration also increased expression of the proinflammatory mediators, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha), macrophage chemotactic protein-1 (MCP-1), and KC/gro, and the anti-inflammatory cytokine, interleukin-10 (IL-10).
Gene_expression (expression) of gro in macrophage associated with necrosis, paracetamol, inflammation, cancer and cytokine
19) Confidence 0.58 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 1.30 Pain Relevance 0.97
Overall, there were significant effects from both mechanical ventilation and genotype on expression of KC/CXCL1, MCP1/CCL2, MIP1?
Gene_expression (expression) of CXCL1
20) Confidence 0.58 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.10 Pain Relevance 0.12

General Comments

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