INT129212

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.90
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (RYBP, Tnf) nucleoplasm (RYBP) extracellular matrix organization (Tnf)
DNA binding (RYBP) cytoplasm (RYBP) cell proliferation (Tnf)
RYBP (Homo sapiens)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 23 100.00 Very High Very High Very High
Inflammation 4 97.68 Very High Very High Very High
cytokine 3 97.16 Very High Very High Very High
Inflammatory mediators 1 67.52 Quite High
chemokine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 8 99.16 Very High Very High Very High
INFLAMMATION 5 97.68 Very High Very High Very High
Necrosis 4 87.48 High High
Cancer 2 87.12 High High
Hypoxia 1 83.20 Quite High
Targeted Disruption 2 76.88 Quite High
Toxicity 3 75.00 Quite High
Stress 3 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
APAP-induced Positive_regulation (increases) of TNF-alpha associated with paracetamol and hepatotoxicity
1) Confidence 0.03 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.66 Pain Relevance 0.98
NAC also abrogated APAP-induced increases in TNFalpha, KC/gro, and IL-10, but augmented expression of the anti-inflammatory cytokines interleukin-4 (IL-4) and transforming growth factor-beta (TGFbeta).
APAP Positive_regulation (increases) of TNFalpha associated with paracetamol, inflammation and cytokine
2) Confidence 0.01 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 1.24 Pain Relevance 0.98

General Comments

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