INT129216

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (RYBP, Tnf) nucleoplasm (RYBP) extracellular matrix organization (Tnf)
DNA binding (RYBP) cytoplasm (RYBP) cell proliferation (Tnf)
RYBP (Homo sapiens)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 100.00 Very High Very High Very High
Inflammation 4 97.68 Very High Very High Very High
cytokine 3 97.16 Very High Very High Very High
Inflammatory mediators 1 67.92 Quite High
chemokine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 5 99.56 Very High Very High Very High
INFLAMMATION 5 97.68 Very High Very High Very High
Necrosis 2 87.88 High High
Cancer 1 87.52 High High
Targeted Disruption 2 76.88 Quite High
Stress 3 71.68 Quite High
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NAC also abrogated APAP-induced increases in TNFalpha, KC/gro, and IL-10, but augmented expression of the anti-inflammatory cytokines interleukin-4 (IL-4) and transforming growth factor-beta (TGFbeta).
Negative_regulation (abrogated) of APAP Positive_regulation (increases) of TNFalpha associated with paracetamol, inflammation and cytokine
1) Confidence 0.01 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 16081117 Disease Relevance 1.24 Pain Relevance 0.98

General Comments

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