INT12922

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2011
Negated 6
Speculated 3
Reported most in Body
Documents 115
Total Number 118
Disease Relevance 50.95
Pain Relevance 17.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscles 11
CD86 9
lung 6
microglia 5
T cells 4
Atp9a (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 379 99.98 Very High Very High Very High
medulla 48 99.84 Very High Very High Very High
cytokine 568 99.76 Very High Very High Very High
Dorsal horn 11 99.68 Very High Very High Very High
rheumatoid arthritis 299 99.60 Very High Very High Very High
palliative 10 99.44 Very High Very High Very High
lidocaine 13 99.32 Very High Very High Very High
Spinal cord 339 99.28 Very High Very High Very High
Osteoarthritis 205 99.12 Very High Very High Very High
carbamazepine 9 99.10 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 1034 100.00 Very High Very High Very High
Arthritis 433 99.98 Very High Very High Very High
Candida Infection 685 99.84 Very High Very High Very High
Infection 720 99.76 Very High Very High Very High
Breast Cancer 206 99.76 Very High Very High Very High
Adult Respiratory Distress Syndrome 47 99.64 Very High Very High Very High
Rheumatoid Arthritis 304 99.60 Very High Very High Very High
Targeted Disruption 459 99.58 Very High Very High Very High
Cancer 1356 99.44 Very High Very High Very High
Sprains And Strains 190 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic differences in COL2A1 type IIA expression, triggered directly by the parasite and/or the tissue response to the parasite, could play a role in the continuing postnatal development of pathology associated with congenitally-acquired toxoplasmosis.
Gene_expression (expression) of IIA associated with toxoplasmosis
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.94 Pain Relevance 0.10
Rather we believe that peroxisomal NMM IIA might locally act in force generation and/or contractile function similar as for example observed in cytokinesis and contractile ring formation [64], [65].
Gene_expression (peroxisomal) of IIA
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0.04
The shift from IIA to IIB accompanies chondrocyte differentiation, whereas re-expression of IIA procollagen has been reported in osteoarthritic cartilage, indicating the potential reversion of the cells to a chondroprogenitor cellular phenotype [34].
Gene_expression (expression) of IIA in cartilage associated with osteoarthritis
3) Confidence 0.58 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779424 Disease Relevance 0.10 Pain Relevance 0
Moreover, the expressions of c-Fos, phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha (pCaMK-IIalpha), and phosphorylated cAMP response element-binding protein (pCREB) were increased by a single i.c.v. morphine injection at various time points, but the expressions of phosphorylated extracellular signal-regulated protein kinase1/2 (pERK1/2) and phosphorylated IkappaB (pIkappaB) were not.
Gene_expression (expressions) of IIalpha associated with morphine
4) Confidence 0.58 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.62
Moreover, the expressions of c-Fos, phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha (pCaMK-IIalpha), and phosphorylated cAMP response element-binding protein (pCREB) were increased by a single i.c.v. morphine injection at various time points, but the expressions of phosphorylated extracellular signal-regulated protein kinase1/2 (pERK1/2) and phosphorylated IkappaB (pIkappaB) were not.
Gene_expression (expressions) of IIalpha associated with morphine
5) Confidence 0.58 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19723567 Disease Relevance 0 Pain Relevance 0.63
Interestingly 4 and 7 patients with IIA and IIB TNM disease respectively were classified in the low risk group whereas 7 stage IB patients were classified in the high risk group, underlying the weakness of the AJCC TNM system to accurately stratify patients by risk based on the tumor characteristics only (survival curves for AJCC TNM stages are shown in Fig. 1B).
Gene_expression (disease) of IIA associated with cancer and disease
6) Confidence 0.17 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2865167 Disease Relevance 0.51 Pain Relevance 0
Besides its function as a key regulator for the expression of MHC class II molecule (1, 2), CIITA has been known to play additional roles in Th differentiation and activation-induced cell death (8, 9, 12, 14, 18).
Gene_expression (expression) of class II associated with death
7) Confidence 0.17 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.59 Pain Relevance 0.15
In addition to its control over expression of various genes including MHC class II, CIITA has also been postulated to participate in CD4+ Th cell differentiation.
Gene_expression (expression) of class II
8) Confidence 0.15 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.14 Pain Relevance 0.09
Major histocompatibility complex class II transactivator (CIITA), a non-DNA-binding transcription factor, is required for expression of MHC class II and other genes related to antigen (Ag) presentation in both conventional and non-conventional antigen-presenting cells (APCs) (1-3).
Gene_expression (expression) of class II
9) Confidence 0.13 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.09 Pain Relevance 0
Expression of MHC class II antigen is apparent in the ductal epithelial cells surrounding LF.
Gene_expression (Expression) of class II in epithelial cells
10) Confidence 0.12 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.09 Pain Relevance 0.04
In this respect, myeloid precursor cells were very similar to resting microglial cells, which lack MHC class II and CD86 expression under normal conditions [16].
Gene_expression (expression) of class II in microglial cells
11) Confidence 0.12 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 1.33 Pain Relevance 0.54
TREM2 cross-linking antibodies stimulated phosphorylation of ERK in TREM2-transduced BM-MC (Figure 3), but did not modify cell surface expression of MHC class II, CD80, CD86, CD36, CCR7, and CD11c (Figure S1).
Gene_expression (expression) of class II in CD86
12) Confidence 0.12 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.60 Pain Relevance 0.21
No expression of MHC class II, CD80, CD86, CD133, Sca1, and c-kit (CD117) was detected, indicating that BM-MC still have an immature phenotype, but without expressing stem cell surface markers (Figure 2A).
Gene_expression (expression) of class II in stem cell
13) Confidence 0.12 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 0.33 Pain Relevance 0.09
Furthermore, myeloid precursor cells used in our study failed to express MHC class II and costimulatory molecules required for antigen presentation to auto-reactive CD4+ T cells.
Gene_expression (express) of class II in precursor cells
14) Confidence 0.12 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1851623 Disease Relevance 1.20 Pain Relevance 0.44
We only occasionally detected expression of MHC class I or MHC class II on individual perivascular cells suggesting that MHC-positive cells rarely reside within CVOs of healthy mice.
Gene_expression (expression) of class II
15) Confidence 0.11 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.82 Pain Relevance 0.17
Flow cytometry dot-plot raw data from representative cases are presented in Figure 2A-F, illustrating the strategy for determination of positivity for HLA class II expression on T cells.
Gene_expression (expression) of class II in T cells
16) Confidence 0.11 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 1.03 Pain Relevance 0
T cell activation, as determined by the presence of surface expression of HLA class II (known from in vitro to become detectable at 2-3 days after stimulation), was found to be strongly enhanced in the EBV patients, and notably not only in the CD8+ T cells but also markedly, although to a lesser degree, in the CD4+ T helper cells (Figure 1B).
Gene_expression (expression) of class II in T cells associated with epstein-barr virus
17) Confidence 0.11 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.94 Pain Relevance 0
Non-adherent and loosely adherent cells were harvested on day 6 as immature DC (typically contained >90% cells expressing CD11c and MHC class II on the surface, as determined by flow cytometry).


Gene_expression (expressing) of class II
18) Confidence 0.10 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.23 Pain Relevance 0
BMDCs were then activated with either LPS or poly I:C, which resulted in enhanced CD86 and MHC class II expression on BMDCs (Fig. 7 B).
Gene_expression (expression) of class II in CD86
19) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.32 Pain Relevance 0.03
Interleukin-10 (IL-10) is a cytokine that may contribute to inflammation and pathogenesis in various autoimmune diseases, due to its function in regulating the proliferation and differentiation of B cells and in enhancing MHC class II antigen expression [66].
Gene_expression (expression) of class II in B cells associated with autoimmune disease, inflammation and cytokine
20) Confidence 0.09 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.42 Pain Relevance 0.19

General Comments

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