INT129227

Context Info Confidence 0.14 First Reported 2005 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 6 Disease Relevance 2.54 Pain Relevance 0.54

nuclear envelope (DNASE1) extracellular region (DNASE1) nucleus (DNASE1)

DNASE1 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 9 99.66 Angina 2 74.84 Inflammation 10 25.28 iatrogenic 4 5.00 Chronic pancreatitis 3 5.00 headache 3 5.00 Analgesic 2 5.00 abdominal pain 1 5.00 backache 1 5.00

Disease Link Frequency Relevance Heat Overdose 5 99.84 Dyspnea 4 98.96 Death 18 98.52 Adhesions 2 97.60 Stress 1 95.64 Suppuration 20 95.20 Infection 53 91.36 Apoptosis 1 88.72 Necrosis 4 87.32 Cancer 13 86.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Intrapleural DNase

DNase Binding (Intrapleural) of

1) Confidence 0.14 Published 2010 Journal Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine Section Body Doc Link PMC2998927 Disease Relevance 0.92 Pain Relevance 0.07

DNase alone appears to be associated with increased frequency of surgery/death.

DNase Binding (associated) of associated with death

2) Confidence 0.13 Published 2010 Journal Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine Section Body Doc Link PMC2998927 Disease Relevance 0.73 Pain Relevance 0

After the treatment with DNase, the 0.1-2 ?

DNase Binding (treatment) of

3) Confidence 0.08 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2867810 Disease Relevance 0 Pain Relevance 0

Additional processing, such as treating the specimens with DNase, reduced the background signal and increased the percentage of viral reads in some instances (data not shown).

DNase Binding (specimens) of

4) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2290972 Disease Relevance 0.13 Pain Relevance 0

In contrast, nDNA fragmentation after AAP overdose is not caused by caspase-activated DNase but most likely by other intracellular DNase(s), whose activation is dependent on the mitochondrial oxidant stress and peroxynitrite formation.

DNase Spec (likely) Binding (caused) of associated with stress, paracetamol and overdose

5) Confidence 0.05 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16081675 Disease Relevance 0.76 Pain Relevance 0.47

-actin mRNA, the combination of DNAse and RNAse completely eliminates ?

DNAse Binding (combination) of

6) Confidence 0.03 Published 2007 Journal Virol J Section Body Doc Link PMC1950496 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.