INT129231

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Context Info
Confidence 0.63
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 9.73
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Ddx41) RNA binding (Ddx41) nucleus (Ddx41)
helicase activity (Ddx41) biological_process (Ddx41)
Anatomy Link Frequency
lumen 3
HeLa 2
T cells 2
CII 1
trachea 1
Ddx41 (Mus musculus)
Pain Link Frequency Relevance Heat
spondylitis 9 99.10 Very High Very High Very High
cva 20 96.00 Very High Very High Very High
tolerance 44 89.96 High High
rheumatoid arthritis 69 87.60 High High
Arthritis 215 85.56 High High
cytokine 53 80.12 Quite High
chemokine 19 73.36 Quite High
spinal inflammation 2 67.36 Quite High
Spinal cord 12 63.52 Quite High
anesthesia 21 60.76 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 3 100.00 Very High Very High Very High
Chlamydia Infection 67 99.72 Very High Very High Very High
Alagille Syndrome 12 99.48 Very High Very High Very High
Low Back Pain 11 99.10 Very High Very High Very High
Cognitive Disorder 39 98.96 Very High Very High Very High
Coma 3 98.54 Very High Very High Very High
Toxicity 131 97.52 Very High Very High Very High
Systemic Lupus Erythematosus 87 97.44 Very High Very High Very High
Weight Loss 31 96.88 Very High Very High Very High
Cv General 3 Under Development 20 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As such locally produced Abs, particularly J-chain associated IgA and IgM, can be expected to be delivered more effectively into the airway lumen than into the intravascular compartment, serum Ab titers do not provide a reliable measure of the locally produced fraction of Abs.
Gene_expression (produced) of Abs in lumen
1) Confidence 0.63 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0 Pain Relevance 0
Second, the absence of correlation between M2e(pep-nat)-specific serum Ab titers and protection in mice immunized by the i.n. route indicated that M2e(pep-nat)-specific serum Abs were not the sole effectors of protection; conceivably, M2e-specific Abs produced in airway tissues, whose titers are inadequately reflected in serum, or M2e-specific T cells may contribute to protection.
Gene_expression (produced) of Abs in T cells
2) Confidence 0.63 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.24 Pain Relevance 0
Immunosorbent-bound Abs were detected with biotinylated mAb 187 (ATCC HB58, rat-anti-mouse ?
Gene_expression (detected) of Abs
3) Confidence 0.55 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.12 Pain Relevance 0
- or G2a-expressing Abs, respectively.
Gene_expression (expressing) of Abs
4) Confidence 0.55 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.11 Pain Relevance 0
As such locally produced Abs, particularly J-chain associated IgA and IgM, can be expected to be delivered more effectively into the airway lumen than into the intravascular compartment, serum Ab titers do not provide a reliable measure of the locally produced fraction of Abs.
Gene_expression (produced) of Abs in lumen
5) Confidence 0.55 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0 Pain Relevance 0
For measurement of Abs specific for cell-expressed (presumably native tetrameric) M2e, we used HeLa cells stably transfected with M2-expressing (HeLa-M2) or empty control plasmid (HeLa-C10) as specific and non-specific (background) immunosorbent, respectively [13].
Gene_expression (expressing) of Abs in HeLa
6) Confidence 0.48 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.35 Pain Relevance 0.09
As such locally produced Abs, particularly J-chain associated IgA and IgM, can be expected to be delivered more effectively into the airway lumen than into the intravascular compartment, serum Ab titers do not provide a reliable measure of the locally produced fraction of Abs.
Gene_expression (produced) of Abs in lumen
7) Confidence 0.48 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0 Pain Relevance 0
Abs specific for cell-expressed, presumably native, tetrameric M2e were measured by using HeLa-M2 cells as specific and HeLa-C10 cells as non-specific immunosorbents.
Gene_expression (expressed) of Abs in HeLa
8) Confidence 0.48 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.16 Pain Relevance 0
The relation between M2e(pep-nat)-specific Ab titers in sera of parenterally vaccinated mice and strength of protection followed sigmoidal curves (Fig 6A), which suggested that M2e(pep-nat)-specific serum Abs were equally protective in nose, trachea and lung (EC50~20 ?
Gene_expression (protective) of Abs in lung
9) Confidence 0.48 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0 Pain Relevance 0
Abs of G2a isotype have often been found to display higher activity in vivo than Abs of other IgG isotypes.
Gene_expression (isotype) of Abs
10) Confidence 0.48 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.19 Pain Relevance 0
The absence of PG-specific (including autoreactive) serum Abs in mice receiving T-depleted cell transfer, despite a B-cell pool of normal size, indicates a requirement for robust T-cell help for effective production of Ag-specific Abs by B cells.
Gene_expression (production) of Abs in B cells
11) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.94 Pain Relevance 0.32
However, these Abs were completely absent in the sera of T-depleted donor cell recipients (Figure 6a, b; N.D.: not detectable).
Neg (absent) Gene_expression (absent) of Abs
12) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.25 Pain Relevance 0
No antidonor Abs were detectable in chimeras treated with Tregs at any time point, whereas control mice (BMT recipients receiving the same regimen without Tregs) developed substantial levels of antidonor Abs at late time points (data not shown).
Gene_expression (detectable) of Abs
13) Confidence 0.20 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0 Pain Relevance 0.20
The relation between M2e(pep-nat)-specific Ab titers in sera of parenterally vaccinated mice and strength of protection followed sigmoidal curves (Fig 6A), which suggested that M2e(pep-nat)-specific serum Abs were equally protective in nose, trachea and lung (EC50~20 ?
Gene_expression (protective) of Abs in trachea
14) Confidence 0.16 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0 Pain Relevance 0
The relation between M2e(pep-nat)-specific Ab titers in sera of parenterally vaccinated mice and strength of protection followed sigmoidal curves (Fig 6A), which suggested that M2e(pep-nat)-specific serum Abs were equally protective in nose, trachea and lung (EC50~20 ?
Gene_expression (protective) of Abs in nose
15) Confidence 0.16 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0 Pain Relevance 0
CII-specific Abs were detected using a standard indirect ELISA in which 500 ng of CII was absorbed to each well of a 96-well microtitre plate.
Gene_expression (detected) of Abs in CII
16) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0 Pain Relevance 0.03
To confirm that anti-INA aAbs are found in the sera of NPSLE patients, purified His-tagged recombinant human INA was used in a western blot.
Gene_expression (found) of aAbs
17) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886066 Disease Relevance 0.32 Pain Relevance 0.03
In contrast, Chlamydia-specific IgG Abs were not detected in vaginal secretions.
Neg (not) Gene_expression (detected) of Abs associated with chlamydia infection
18) Confidence 0.10 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.84 Pain Relevance 0.18
The titer of the Ab was inversely correlated with the cognitive status as measured by Glasgow coma scale or Mini Mental State Examination (MMSE) in the NPSLE patients who had anti-INA Abs in their CSF (Figure 3C).


Gene_expression (had) of Abs associated with cognitive disorder and coma
19) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886066 Disease Relevance 1.17 Pain Relevance 0.07
We tested for anti-INA aAbs in the sera of NPSLE (n?
Gene_expression (tested) of aAbs
20) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886066 Disease Relevance 0.74 Pain Relevance 0.14

General Comments

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