INT129239

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.81
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
lymphocyte 2
Th1 cells 2
T-lymphocyte 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 50 100.00 Very High Very High Very High
withdrawal 11 100.00 Very High Very High Very High
Morphine 8 99.98 Very High Very High Very High
Inflammation 114 98.28 Very High Very High Very High
Analgesic 1 70.16 Quite High
opiate 1 69.72 Quite High
chemokine 16 5.00 Very Low Very Low Very Low
Arthritis 15 5.00 Very Low Very Low Very Low
Crohn's disease 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 10 99.48 Very High Very High Very High
Systemic Sclerosis 30 98.92 Very High Very High Very High
INFLAMMATION 119 98.28 Very High Very High Very High
Atherosclerosis 67 96.80 Very High Very High Very High
Injury 12 93.52 High High
Atherosclerotic Plaque 28 88.80 High High
Disease 35 87.60 High High
Sclerosis 4 85.40 High High
Hypersensitivity 27 84.08 Quite High
Adhesions 10 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, Western blot and EMSA experiments revealed that morphine withdrawal-induced Th2 differentiation was mediated through the classical Th2 transcription factors Stat-6 and GATA-3.
Positive_regulation (mediated) of Positive_regulation (withdrawal-induced) of Th2 associated with withdrawal and morphine
1) Confidence 0.43 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081842 Disease Relevance 0 Pain Relevance 1.41
Expression of twist1 increases upon repeated restimulation in vitro in Th1 cells, whereas it is not induced even in repeatedly restimulated Th2 or Th17 cells.
Neg (not) Positive_regulation (induced) of Positive_regulation (restimulated) of Th2 in Th1 cells
2) Confidence 0.17 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.16 Pain Relevance 0.08
Allergic asthma is often associated with activation of IL-5 gene cluster, a pattern compatible with predominant activation of Th2-like T-lymphocyte population.
Positive_regulation (activation) of Positive_regulation (activation) of Th2-like in T-lymphocyte associated with asthma
3) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.64 Pain Relevance 0.24
deletion of STAT6, a transcription factor required for the activation of Th2
Positive_regulation (required) of Positive_regulation (activation) of Th2
4) Confidence 0.07 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2423423 Disease Relevance 0.84 Pain Relevance 0.14
SSc has been associated with T helper lymphocyte type-2 (TH-2) activation, cytokine production (particularly Il-4, IL-13, and IL-17), and excess collagen accumulation, which could participate in the development of vasculopathy [7].
Positive_regulation (excess) of Positive_regulation (activation) of TH-2 in lymphocyte associated with systemic sclerosis and cytokine
5) Confidence 0.01 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958499 Disease Relevance 1.17 Pain Relevance 0.05

General Comments

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