INT12924

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Context Info
Confidence 0.30
First Reported 1991
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 6.59
Pain Relevance 6.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nephron 4
epithelial cells 4
cardiac myocytes 2
colon 2
apical cell 2
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 101 100.00 Very High Very High Very High
Endep 20 99.98 Very High Very High Very High
tetrodotoxin 84 99.84 Very High Very High Very High
Pyramidal cell 6 99.20 Very High Very High Very High
Mexiletine 19 98.98 Very High Very High Very High
cytokine 189 98.80 Very High Very High Very High
local anesthetic 7 98.80 Very High Very High Very High
Pain 8 97.88 Very High Very High Very High
imagery 15 97.72 Very High Very High Very High
anticonvulsant 2 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 56 99.62 Very High Very High Very High
Natriuresis 22 99.36 Very High Very High Very High
Pain 8 97.88 Very High Very High Very High
Pyelonephritis 36 97.44 Very High Very High Very High
Diuresis 28 97.32 Very High Very High Very High
Diarrhoea 80 95.08 Very High Very High Very High
INFLAMMATION 508 94.00 High High
Renal Disease 9 93.28 High High
Neuropathic Pain 4 88.96 High High
Disease 94 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As suggested by recent studies, the decrease of Na+ channel expression and the changes of the electrophysiological properties during the postnatal maturation of the CNS seem to exclude the possibility that astrocytes may play an excitable role in adult tissue.
Negative_regulation (decrease) of Gene_expression (expression) of Na in astrocytes
1) Confidence 0.30 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11029624 Disease Relevance 0.17 Pain Relevance 0.16
Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs.
Negative_regulation (inhibition) of Gene_expression (expressed) of Na associated with anticonvulsant and local anesthetic
2) Confidence 0.24 Published 1991 Journal Mol. Pharmacol. Section Title Doc Link 1658608 Disease Relevance 0 Pain Relevance 0.40
Taken together, these results show that UC results mainly in decreased expression of the apical ENaC beta- and gamma-subunits, as well as the basolateral Na+, K+-ATPase alpha1- and beta1-isoforms.
Negative_regulation (decreased) of Gene_expression (expression) of Na associated with inflammatory bowel disease
3) Confidence 0.23 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.59 Pain Relevance 0.07
We have developed an analogue of mexiletine which is approximately 80 times more potent than mexiletine in competing with the radioligand, 3H-batrachotoxinin for binding to Na+ channels in rat brain membranes and also it is much more lipophilic than mexiletine which should enhance its uptake into the brain to block the increased expression of Na+ channels on second- and third-order neurons of the pain pathway.
Negative_regulation (block) of Gene_expression (expression) of Na in brain associated with pain and mexiletine
4) Confidence 0.22 Published 2009 Journal Neurochem. Res. Section Abstract Doc Link 19504185 Disease Relevance 0.49 Pain Relevance 1.02
Decreased expression of apical Na+ channels and basolateral Na+, K+-ATPase in ulcerative colitis.
Negative_regulation (Decreased) of Gene_expression (expression) of Na associated with inflammatory bowel disease
5) Confidence 0.17 Published 2004 Journal J. Pathol. Section Title Doc Link 15307141 Disease Relevance 0.83 Pain Relevance 0.07
In addition, the Na+ channels expressed in these cells are blocked by tetrodotoxin with an IC50 value of 2.5 microM; consistent with known cardiac Na+ channel pharmacology.
Negative_regulation (blocked) of Gene_expression (expressed) of Na associated with tetrodotoxin
6) Confidence 0.16 Published 1995 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 7776389 Disease Relevance 0 Pain Relevance 0.10
The Na+ content of calres cells was measured in 5 samples from a single donor from blood drawn on different days; the Na+ content of the calres cells was (mean ± SEM) 51.6 ± 4.3 mmol(340 g Hb)?
Negative_regulation (measured) of Gene_expression (content) of Na in blood
7) Confidence 0.08 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0
In this study, marked natriuresis (in terms of increased urinary Na+ level and sodium saliuretic index) was evident possibly because of the inhibition of Na+ resorption in the nephron,[4] thereby increasing the urinary output.
Spec (possibly) Negative_regulation (inhibition) of Gene_expression (resorption) of Na in nephron associated with natriuresis
8) Confidence 0.08 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2992138 Disease Relevance 0.39 Pain Relevance 0
In this study, marked natriuresis (in terms of increased urinary Na+ level and sodium saliuretic index) was evident possibly because of the inhibition of Na+ resorption in the nephron,[4] thereby increasing the urinary output.
Spec (possibly) Negative_regulation (inhibition) of Gene_expression (resorption) of Na in nephron associated with natriuresis
9) Confidence 0.08 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2992138 Disease Relevance 0.38 Pain Relevance 0
A reduced aldosterone effect on tissues could lead to a reduction of Na/K ATPase expression and activity.
Negative_regulation (reduction) of Gene_expression (expression) of Na
10) Confidence 0.06 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.28 Pain Relevance 0.24
PGE2 supports the inhibition of ENaC at the apical cell membrane by inducing a concomitant reduction in the activity or expression of the Na/K ATPase at the basolateral membrane.
Negative_regulation (reduction) of Gene_expression (expression) of Na in apical cell
11) Confidence 0.06 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.85 Pain Relevance 0.31
Results of real-time RT-PCR indicated that AMI inhibited the expression for sodium channels in a concentration-dependent manner; inhibition of expression of the Na(V)1.1 and Na(V)1.6 sodium channels was more than that of Na(V)1.2.
Negative_regulation (inhibition) of Gene_expression (expression) of Na associated with sodium channel and endep
12) Confidence 0.05 Published 2010 Journal Brain Res. Section Abstract Doc Link 20398637 Disease Relevance 0.52 Pain Relevance 1.27
This cytokine increased protein expression of the Na K 2Cl symporter and reduced Na/K ATPase protein expression in another experiment [87].
Negative_regulation (reduced) of Gene_expression (expression) of Na associated with cytokine
13) Confidence 0.05 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.15 Pain Relevance 0.08
TNF was found to have the opposite effect on Na K 2Cl symporter expression in rat colon where it reduced both Na/K ATPase and Na K 2Cl symporter expression and activity in surface and crypt colonocytes [88].
Negative_regulation (reduced) of Gene_expression (expression) of Na in colon
14) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.16 Pain Relevance 0.07
IFN gamma reduced Na/K/2Cl-cotransporter and Na/K ATPase expression without altering CFTR levels in T84 intestinal epithelial cells [91].
Negative_regulation (reduced) of Gene_expression (expression) of Na in epithelial cells
15) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.08 Pain Relevance 0.03
PGE2 in turn inhibited NF-kappaB and reduced the protein expression of Na/K ATPase [100].
Negative_regulation (reduced) of Gene_expression (expression) of Na
16) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.33 Pain Relevance 0.28
IFN gamma reduced Na/K/2Cl-cotransporter and Na/K ATPase expression without altering CFTR levels in T84 intestinal epithelial cells [91].
Negative_regulation (reduced) of Gene_expression (expression) of Na in epithelial cells
17) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.08 Pain Relevance 0.03
Another study however noted that interferon gamma reduced Na/K ATPase activity without change in Na K ATPase expression in human intestinal Caco-2 cells [59].
Negative_regulation (reduced) of Gene_expression (expression) of Na in Caco-2
18) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.23 Pain Relevance 0
IL 1beta inhibited protein expression of Na/K ATPase in medullary and cortical rat kidney cells and this effect was mediated by the extracellular signal regulated protein kinase pathway which activated the nuclear factor NF-kappaB, thus leading to increased cycloxyenase-2 [COX-2] expression and PGE2 release.
Negative_regulation (inhibited) of Gene_expression (expression) of Na in kidney
19) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.26 Pain Relevance 0.28
Results of real-time RT-PCR indicated that AMI inhibited the expression for sodium channels in a concentration-dependent manner; inhibition of expression of the Na(V)1.1 and Na(V)1.6 sodium channels was more than that of Na(V)1.2.
Negative_regulation (inhibited) of Gene_expression (expression) of Na associated with sodium channel and endep
20) Confidence 0.04 Published 2010 Journal Brain Res. Section Abstract Doc Link 20398637 Disease Relevance 0.55 Pain Relevance 1.31

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