INT129240

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.96
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat6) nucleus (Stat6) DNA binding (Stat6)
cytoplasm (Stat6) signal transducer activity (Stat6)
Anatomy Link Frequency
CD86 1
B cell 1
lung 1
Stat6 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 11 99.34 Very High Very High Very High
cytokine 167 99.30 Very High Very High Very High
Morphine 8 99.12 Very High Very High Very High
Central nervous system 8 73.28 Quite High
Analgesic 5 68.44 Quite High
opiate 1 68.00 Quite High
chemokine 2 60.12 Quite High
palliative 3 50.00 Quite Low
Inflammation 70 39.68 Quite Low
alcohol 5 37.32 Quite Low
Disease Link Frequency Relevance Heat
Asthma 25 98.48 Very High Very High Very High
Pulmonary Eosinophilia 1 95.88 Very High Very High Very High
Targeted Disruption 19 93.12 High High
Diabetes Mellitus 3 85.44 High High
Obesity 3 84.92 Quite High
Metabolic Disorder 1 84.28 Quite High
Mucositis 74 83.60 Quite High
Infection 220 81.24 Quite High
Insulin Resistance 3 78.40 Quite High
Cold Sores 214 71.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Others have also examined STAT-6 activation in lung tissue[22].
Spec (examined) Positive_regulation (activation) of STAT-6 in lung
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.29 Pain Relevance 0.09
In addition, Western blot and EMSA experiments revealed that morphine withdrawal-induced Th2 differentiation was mediated through the classical Th2 transcription factors Stat-6 and GATA-3.
Positive_regulation (mediated) of Stat-6 associated with withdrawal and morphine
2) Confidence 0.49 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081842 Disease Relevance 0 Pain Relevance 1.42
STAT6 signaling pathway, for instance, is constitutively activated in immature dendritic populations and declines as these cells mature.
Positive_regulation (activated) of STAT6
3) Confidence 0.38 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.19 Pain Relevance 0.09
concentrations, activated STAT6 is no longer able to compete with the high amounts of activated STAT1 dimer [440].
Positive_regulation (activated) of STAT6
4) Confidence 0.33 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.57 Pain Relevance 0.04
This interaction of SOCS5 with the IL-4 receptor is likely to cause the reduction in IL-4-induced activation of STAT6 and thus to regulate Th2 polarization.
Positive_regulation (activation) of STAT6
5) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.92 Pain Relevance 0
CD86 was shown to be differentially regulated by various cytokines including Th2 promoting IL-4, via activation of MAP kinase and Stat6 [41].
Positive_regulation (activation) of Stat6 in CD86 associated with cytokine
6) Confidence 0.16 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.14
Following secretion, these cytokines bind to corresponding receptors (IL-13R or IL-4R) on the B cell, leading to STAT6 activation in B cells.
Positive_regulation (activation) of STAT6 in B cell associated with cytokine
7) Confidence 0.07 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0 Pain Relevance 0.16

General Comments

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