INT129253

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.97
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
muscle 2
hippocampus 2
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 100 99.98 Very High Very High Very High
Hippocampus 9 99.84 Very High Very High Very High
agonist 66 94.88 High High
Eae 1 84.92 Quite High
cytokine 39 80.56 Quite High
anesthesia 8 77.68 Quite High
nMDA receptor 9 75.52 Quite High
Hyperalgesia 77 67.36 Quite High
Lasting pain 9 43.76 Quite Low
nMDA receptor antagonist 2 22.32 Low Low
Disease Link Frequency Relevance Heat
Brain Injury 26 100.00 Very High Very High Very High
INFLAMMATION 110 99.98 Very High Very High Very High
Body Weight 1 84.12 Quite High
Dermatitis 2 77.20 Quite High
Death 2 73.80 Quite High
Hyperalgesia 77 67.36 Quite High
Neurodegenerative Disease 2 66.36 Quite High
Injury 12 59.28 Quite High
Cognitive Disorder 4 50.00 Quite Low
Pain 21 42.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of IL-1alpha RNA and protein were significantly elevated at 3 h after TBI, peaked at 12 h, and remained elevated for 168 h.
Positive_regulation (elevated) of Positive_regulation (Levels) of IL-1alpha associated with brain injury
1) Confidence 0.49 Published 2005 Journal J. Neurotrauma Section Abstract Doc Link 16083355 Disease Relevance 1.17 Pain Relevance 0.20
Levels of IL-1alpha RNA and protein were significantly elevated at 3 h after TBI, peaked at 12 h, and remained elevated for 168 h.
Positive_regulation (elevated) of Positive_regulation (Levels) of IL-1alpha associated with brain injury
2) Confidence 0.49 Published 2005 Journal J. Neurotrauma Section Abstract Doc Link 16083355 Disease Relevance 1.15 Pain Relevance 0.20
Masseter muscle inflammation induced a significant upregulation of IL-1?
Positive_regulation (induced) of Positive_regulation (upregulation) of IL-1 in muscle associated with inflammation
3) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.57 Pain Relevance 0.42
, with the phosphorylation of JNK and p38 MAPK being obvious from 5 to 15 minutes and of ERK1/2 from 5 to 30 minutes after IL-1?
Positive_regulation (obvious) of Positive_regulation (minutes) of IL-1
4) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0 Pain Relevance 0.40
g) in the hippocampus highly induced the increase of IL-1?
Positive_regulation (induced) of Positive_regulation (increase) of IL-1 in hippocampus associated with hippocampus
5) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1693919 Disease Relevance 0.08 Pain Relevance 0.09

General Comments

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