INT129303

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 54
Total Number 61
Disease Relevance 36.92
Pain Relevance 57.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) cytoplasm (NAV1)
Anatomy Link Frequency
Caov-3 4
tooth pulp 3
neuronal 3
nodes 3
nasal mucosa 3
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 1359 100.00 Very High Very High Very High
sodium channel 1305 100.00 Very High Very High Very High
nav1.8 125 100.00 Very High Very High Very High
Nav1.9 120 100.00 Very High Very High Very High
Nav1.1 49 100.00 Very High Very High Very High
nav1.3 43 100.00 Very High Very High Very High
Nav1.2 28 100.00 Very High Very High Very High
Nav1.6 23 100.00 Very High Very High Very High
Calcitonin gene-related peptide 5 100.00 Very High Very High Very High
Neuropeptide 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 176 99.92 Very High Very High Very High
Hyperalgesia 33 99.92 Very High Very High Very High
Demyelinating Disease 63 99.82 Very High Very High Very High
INFLAMMATION 216 99.76 Very High Very High Very High
Hypersensitivity 69 99.76 Very High Very High Very High
Headache 7 99.70 Very High Very High Very High
Burning Mouth Syndrome 507 99.60 Very High Very High Very High
Targeted Disruption 20 99.60 Very High Very High Very High
Somatoform Disorder 93 99.42 Very High Very High Very High
Ovarian Cancer 28 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nav1.9 channel immunoreactivity on pulpal axons was significantly increased in painful teeth.
Positive_regulation (increased) of Nav1 in teeth associated with pain and nav1.9
1) Confidence 0.70 Published 2007 Journal J Endod Section Abstract Doc Link 17889684 Disease Relevance 0.51 Pain Relevance 1.65
We found that Nav1.7 was downregulated in TN (P=0.017) and Nav1.3 was upregulated in these patients (P=0.043).
Positive_regulation (upregulated) of Nav1 associated with nav1.3, trigeminal neuralgia and nav1.7
2) Confidence 0.70 Published 2009 Journal Neuroscience Section Abstract Doc Link 19699781 Disease Relevance 1.05 Pain Relevance 1.98
Our previous study demonstrated an increase of sodium channels Nav1.7, Nav1.8 and Nav1.9 in hypersensitivity states of nasal mucosa in patients with allergic and non-allergic rhinitis [21].
Positive_regulation (increase) of Nav1 in nasal mucosa associated with rhinitis, hypersensitivity, sodium channel, nav1.8, nav1.7 and nav1.9
3) Confidence 0.70 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.39 Pain Relevance 1.83
Our previous study demonstrated an increase of sodium channels Nav1.7, Nav1.8 and Nav1.9 in hypersensitivity states of nasal mucosa in patients with allergic and non-allergic rhinitis [21].
Positive_regulation (increase) of Nav1 in nasal mucosa associated with rhinitis, hypersensitivity, sodium channel, nav1.8, nav1.7 and nav1.9
4) Confidence 0.70 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.41 Pain Relevance 1.84
As we did not observe a significant change in TRPV1 immunoreactivity levels in painful dental pulpitis compared to non-painful tooth pulp [33], there appears to be differential expression of sodium and TRP channels in trigeminal pain disorders - further studies are required to confirm the increase of Nav1.7, Nav1.8 and Nav1.9 in inflammatory and TRPV1 in neuropathic trigeminal pain states.
Positive_regulation (increase) of Nav1 in tooth pulp associated with pain, inflammation, trp channel, pulpitis, neuropathic pain, nav1.8, nav1.7 and nav1.9
5) Confidence 0.70 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.49 Pain Relevance 2.01
As we did not observe a significant change in TRPV1 immunoreactivity levels in painful dental pulpitis compared to non-painful tooth pulp [33], there appears to be differential expression of sodium and TRP channels in trigeminal pain disorders - further studies are required to confirm the increase of Nav1.7, Nav1.8 and Nav1.9 in inflammatory and TRPV1 in neuropathic trigeminal pain states.
Positive_regulation (increase) of Nav1 in tooth pulp associated with pain, inflammation, trp channel, pulpitis, neuropathic pain, nav1.8, nav1.7 and nav1.9
6) Confidence 0.70 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.49 Pain Relevance 2.07
Our previous study demonstrated an increase of sodium channels Nav1.7, Nav1.8 and Nav1.9 in hypersensitivity states of nasal mucosa in patients with allergic and non-allergic rhinitis [21].
Positive_regulation (increase) of Nav1 in nasal mucosa associated with rhinitis, hypersensitivity, sodium channel, nav1.8, nav1.7 and nav1.9
7) Confidence 0.70 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.40 Pain Relevance 1.84
As we did not observe a significant change in TRPV1 immunoreactivity levels in painful dental pulpitis compared to non-painful tooth pulp [33], there appears to be differential expression of sodium and TRP channels in trigeminal pain disorders - further studies are required to confirm the increase of Nav1.7, Nav1.8 and Nav1.9 in inflammatory and TRPV1 in neuropathic trigeminal pain states.
Positive_regulation (increase) of Nav1 in tooth pulp associated with pain, inflammation, trp channel, pulpitis, neuropathic pain, nav1.8, nav1.7 and nav1.9
8) Confidence 0.70 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.49 Pain Relevance 2.01
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Positive_regulation (increased) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
9) Confidence 0.70 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.68 Pain Relevance 0.65
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Positive_regulation (increased) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
10) Confidence 0.70 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.68 Pain Relevance 0.65
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Positive_regulation (increased) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
11) Confidence 0.70 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.68 Pain Relevance 0.65
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Positive_regulation (increased) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
12) Confidence 0.70 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.68 Pain Relevance 0.65
For example, the accumulation of Nav1.7 appeared greater in painful human neuromas when compared to nonpainful ones [19], yet a quantitative evaluation within human lingual nerve neuromas suggests that Nav1.7 expression alone is not correlated with the presence of painful dysesthesia [20].
Positive_regulation (accumulation) of Nav1 in nerve associated with pain, dysesthesia, neuroma and nav1.7
13) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 1.72 Pain Relevance 2.06
This evaluation further allowed the characterization of Nav1.7 at some caspr-identified atypical sites that were classified as split nodes where two distinct Nav1.7 accumulations were separated by a gap in the Nav1.7 staining within the same fiber and with each Nav1.7 accumulation being flanked on only one side by caspr.


Positive_regulation (accumulations) of Nav1 in nodes associated with nav1.7
14) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.91
The V1/2 of activation of WT Nav1.4, however, has been reported to shift in a depolarizing direction upon cooling [33].
Positive_regulation (activation) of Nav1 associated with nav1.7
15) Confidence 0.69 Published 2007 Journal Mol Pain Section Body Doc Link PMC1781932 Disease Relevance 1.18 Pain Relevance 0.98
The V1/2 of activation of WT Nav1.5 does not show temperature sensitivity [32], similar to our findings for WT.
Positive_regulation (activation) of Nav1 associated with nav1.7
16) Confidence 0.69 Published 2007 Journal Mol Pain Section Body Doc Link PMC1781932 Disease Relevance 1.09 Pain Relevance 0.91
Here, we demonstrate a focal and robust upregulation of sodium channel Nav1.5 in reactive astrocytes at the borders of, and within, active and chronic multiple sclerosis lesions.
Positive_regulation (upregulation) of Nav1 in astrocytes associated with multiple sclerosis and sodium channel
17) Confidence 0.61 Published 2010 Journal Brain Section Abstract Doc Link 20147455 Disease Relevance 0.52 Pain Relevance 0.96
Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5.
Positive_regulation (upregulate) of Nav1 in Astrocytes associated with multiple sclerosis and sodium channel
18) Confidence 0.61 Published 2010 Journal Brain Section Title Doc Link 20147455 Disease Relevance 0.50 Pain Relevance 0.88
Renton et al. (2005) showed a significant increase in Nav1.8 fibres as a proportion of neurofilament positive fibres within painful dental pulp specimens [2].
Positive_regulation (increase) of Nav1 in dental pulp associated with pain and nav1.8
19) Confidence 0.61 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 0.51 Pain Relevance 1.25
RESULTS: We demonstrate upregulation of sodium channel Nav1.3, as well as Nav1.7 and Nav1.8, in blind-ending axons within human painful neuromas.
Positive_regulation (upregulation) of Nav1
20) Confidence 0.61 Published 2008 Journal Ann. Neurol. Section Body Doc Link 19107992 Disease Relevance 0.17 Pain Relevance 0

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