INT129318

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.19
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA)
enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)
Anatomy Link Frequency
lung 1
NFKBIA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 317 99.62 Very High Very High Very High
rheumatoid arthritis 116 96.40 Very High Very High Very High
Inflammatory stimuli 70 92.96 High High
cytokine 92 87.88 High High
Inflammatory response 116 84.60 Quite High
Inflammatory mediators 10 82.56 Quite High
Prostatitis 33 78.72 Quite High
Osteoarthritis 24 75.00 Quite High
Arthritis 9 72.24 Quite High
cINOD 9 70.68 Quite High
Disease Link Frequency Relevance Heat
Pneumonia 1 99.62 Very High Very High Very High
Multiple Myeloma 7 96.88 Very High Very High Very High
Rheumatoid Arthritis 116 96.40 Very High Very High Very High
Stress 8 95.64 Very High Very High Very High
INFLAMMATION 455 94.08 High High
Hypercalcemia 6 93.16 High High
Necrosis 25 91.44 High High
Cancer 35 91.08 High High
Infection 31 88.32 High High
Alagille Syndrome 2 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
Negative_regulation (inhibitor) of IkappaBalpha
1) Confidence 0.38 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 1.15 Pain Relevance 0.38
The protein inhibitor of NF-kB (IkBa) aims at retrieving nuclear concentration of NF-kB with the formation of an inactive complex in the cytoplasm regulating the expression of various inflammatory genes.
Negative_regulation (inhibitor) of IkBa associated with inflammation
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.55 Pain Relevance 0.35
From the modeling point of view, in order to achieve a zero steady state for the protein inhibitor IkBa we need the additional negative term ?
Negative_regulation (inhibitor) of IkBa
3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.08 Pain Relevance 0.04
NFKBIA is an inhibitor of NF-?
Negative_regulation (inhibitor) of NFKBIA
4) Confidence 0.16 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.29 Pain Relevance 0
B, resulting in lung inflammation.30 Phosphorylated IKBa was significantly increased in rats with CP and was significantly decreased in the oligonol-administrated group, suggesting that oligonol inhibits E2-induced CP by regulating phosphorylation of I?
Negative_regulation (decreased) of IKBa in lung associated with inflammation and pneumonia
5) Confidence 0.03 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2703763 Disease Relevance 0.66 Pain Relevance 0.25
The rabbit polyclonal anti-human inhibitor of kappaB-alpha Ab (no. 9242) was purchased from Cell Signaling Technology, Inc.
Negative_regulation (inhibitor) of kappaB-alpha
6) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.17 Pain Relevance 0.08
RANK signaling was analyzed by the degradation of inhibitor of kappaB-alpha (I-?
Negative_regulation (inhibitor) of kappaB-alpha
7) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1906801 Disease Relevance 0.98 Pain Relevance 0.37
SDX-308 effectively suppressed TNF-alpha-induced IKK-gamma and IkappaB-alpha phosphorylation and degradation and subsequent NF-kappaB activation in human multiple myeloma cells.
Negative_regulation (suppressed) of IkappaB-alpha associated with multiple myeloma
8) Confidence 0.02 Published 2007 Journal Blood Section Abstract Doc Link 17095620 Disease Relevance 0.89 Pain Relevance 0.11
B is sequestered by the inhibitor of kappa B (I?
Negative_regulation (inhibitor) of kappa B
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995738 Disease Relevance 0.54 Pain Relevance 0.30
Increases in NF-kappaB nuclear binding were paralleled by decreasing amounts of cytosolic IkappaB-alpha.
Negative_regulation (decreasing) of IkappaB-alpha
10) Confidence 0.01 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 16088959 Disease Relevance 0.90 Pain Relevance 0.14

General Comments

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